| 调气活血补肾汤对慢性肾功能不全大鼠的影响 |
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| 引用本文： | 马文波,郜新春,王建一,杨书文.调气活血补肾汤对慢性肾功能不全大鼠的影响[J].蚌埠医学院学报,2008,33(4):397-399. |
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| 作者姓名： | 马文波 郜新春 王建一 杨书文 |
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| 作者单位： | 1. 河北省张家口市第一医院泌尿外科, 075000;2. 河北北方学院附属第一医院, 河北张家口 075000;3. 河北医科大学附属第二医院, 河北张家口 050061 |
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| 摘 要： | 目的:观察调气活血补肾汤对慢性肾功能不全(CRF)大鼠肾组织匀浆NO及脂质过氧化的影响。方法:Wistar大鼠在乙醚麻醉下,切除5/6肾脏制备慢性肾功能不全模型。5周后,按小剂量(生药13.9 g/kg)、大剂量(生药27.8 g/kg)给模型大鼠灌胃给药,连续10周,于给药4周、10周后分两批处死大鼠,制备肾组织匀浆,测定NO、一氧化氮合酶(NOS)及超氧化物歧化酶(SOD)、丙二醛(MDA)含量。结果:成功复制大鼠CRF模型。CRF大鼠肾匀浆NO和NOS活性呈明显的早期升高、晚期下降趋势;使用调气活血补肾汤治疗4周时显著抑制NO和NOS活性过分明显升高,10周时显著抑制NO和NOS活性过分持续降低。随病程延长CRF大鼠肾组织SOD活性呈逐渐下降,MDA呈逐渐升高的趋势;调气活血补肾汤治疗后肾组织SOD活性明显增强,10周时显著下降,MDA则呈下降趋势;以上作用大剂量药物组均优于小剂量组。结论:调气活血补肾汤能改善和调节肾组织NO合成与释放、降低自由基损伤。
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| 关 键 词： | 肾功能不全 慢性 调气活血补肾汤 一氧化氮 一氧化氮合酶 超氧化物歧化酶 丙二醛 大鼠 |
| 收稿时间： | 2008-01-04 |
Effect of Tiaoqi Huoxue Bushen decoction on experimental renal injury in rats |
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| MA Wen-bo,GAO Xin-chun,WANG Jian-yi,YANG Shu-wen.Effect of Tiaoqi Huoxue Bushen decoction on experimental renal injury in rats[J].Journal of Bengbu Medical College,2008,33(4):397-399. |
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| Authors: | MA Wen-bo GAO Xin-chun WANG Jian-yi YANG Shu-wen |
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| Institution: | 1. Department of Urology Surgery, The Frist Hospital of Zhangjiakou, Zhangjiakou Hebei 075000;2. First Affiliated Hospital, Hebei North University, Zhangjiakou Hebei 075000;3. Second Affiliated Hospital, Hebei Medical University, Shijiazhuang Hebei 050061, China |
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| Abstract: | Objective:To observe the effect of Tiaoqi Huoxue Bushen decoction on the nitric oxide(NO) and lipid overoxidation of renal homogenate in rats with chronic renal failure(CRF).Methods:The Wistar rats were resected five sixths of the kidney under anesthetization by ether to make animal models of chronic renal failure.After 5 weeks,the CRF rats were administered 13.9 g/kg BW and 27.8 g/kg BW for 10 weeks.All the rats were killed after 4 and 10 weeks,and the reanl homogenate was made.The relevant indexes such as... |
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| Keywords: | renal failure chronic Tiaoqi Huoxue Bushen decoction nitric oxide nitric oxide synthase superoxide dismutase malondialdehyde rats |
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