| α-受体拮抗剂降低肝硬变狗门脉压及肝静脉嵌塞压的研究 |
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| 引用本文： | 杨大国,李绍白,过晋源.α-受体拮抗剂降低肝硬变狗门脉压及肝静脉嵌塞压的研究[J].华中科技大学学报(医学版),1988(2). |
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| 作者姓名： | 杨大国 李绍白 过晋源 |
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| 作者单位： | 同济医科大学附属同济医院肝胆研究室内科消化组
(杨大国，李绍白)，同济医科大学附属同济医院肝胆研究室内科消化组(过晋源) |
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| 摘 要： | 本实验成功地建立了狗肝硬变门脉高压症模型,观察了α～受体拈抗剂(酚妥拉明)对狗肝硬变门脉压、肝静脉嵌塞压和肝静脉压力梯度的作用。实验结果表明,酚妥拉明能明显降低狗肝硬变的门脉压、肝静脉嵌塞压和肝静脉压力梯度,分别下降35.2％、37.2％和52.1％。
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| 关 键 词： | α-受体拮抗剂 狗肝硬变 门脉高压症 |
A Study of Alpha-Adrenoceptor Antagonist Decreasing Pressure of Portal Vein and Wedged Hepatic Vein in Liver Cirrhotic Dogs |
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| Yang Daguo,Li Shaobai,Guo JinyuanLaboratory of Liver and Biliary Diseases.A Study of Alpha-Adrenoceptor Antagonist Decreasing Pressure of Portal Vein and Wedged Hepatic Vein in Liver Cirrhotic Dogs[J].Journal of Huazhong University of Science and Technology(Health Sciences),1988(2). |
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| Authors: | Yang Daguo Li Shaobai Guo JinyuanLaboratory of Liver and Biliary Diseases |
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| Institution: | Yang Daguo,Li Shaobai,Guo JinyuanLaboratory of Liver and Biliary Diseases,Department of Medicine,Tongji Hospital,Tongji Medical University,Wuhan |
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| Abstract: | It has been confirmed that regulation of hepatic microvascular beds is mainly controlled by alpha-adrenoceptors. In order to clarify whether alpha-adre-noceptor antagonists arrest the effects of alpha-adrenoceptors on hepatic vascular beds and decrease the pressure of portal vein and w dged hepatic vein in liver cirrhosis, we observed the effect of alpha-adrenoceptor antagonist, (phentolamine, perfused intravenously) on aforementioned pressure in liver cirrhosis induced by dimethyni-trosamine or common bile duct ligation in dogs (n = 6). The experimental results show that phentolamine can markedly reduce portal venous pressure, wedged hepatic venous pressure and hepatic venous pressure gradient on average to 35.2%, 37.2%, 52.1%; P<0.01 respectively. |
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| Keywords: | alpha-adrenoceptor antagonist liver cirrhosis portal hypertension dogs |
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