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Modification of the behavioral response to drugs in rats exposed prenatally to chlorpromazine
Authors:Mari Golub  Conan Kornetsky
Affiliation:(1) Boston University School of Medicine, USA;(2) Present address: 2713 Green Bay Way, 95826 Sacramento, California
Abstract:Female rats exposed prenatally to low levels of chlorpromazine were less susceptible as adults to the rate-reducing effects of chlorpromazine and pentobarbital on fixed-interval performance of a food-reinforced operant. Males were not significantly affected by prenatal treatment.Supported by NIMH grant MH 12568 and Research Scientist Award (Conan Kornetsky) MH 01759. We thank John Rizzo for carrying out the behavioral testing.
Keywords:Prenatal Drug  Albino Rats  Chlorpromazine  Pentobarbital  Operant Conditioning
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