Pharmacokinetics of oral vitamin D3 and calcifediol |
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| Institution: | 1. Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland;2. Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland;3. Centre on Aging and Mobility, City Hospital Waid, Zurich Switzerland;4. Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University, Boston, MA, USA;5. Department of Geriatrics, University of Basel, Basel, Switzerland;6. DSM Nutritional Products Ltd, Basel, Switzerland;7. Dept. of Geriatrics, University Hospital Zurich, Switzerland;1. Laboratory for Biophysics of Macromolecular Aggregates, Department of Biomedical Engineering, Wroc?aw University of Science and Technology, Wroc?aw, Poland;2. Lipid Systems sp. z o.o., Wroc?aw, Poland;3. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland;4. Provincial Integrated Hospital, Leszno;5. Research and Development Centre, Specialized Hospital in Wroc?aw, Wroc?aw, Poland |
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| Abstract: | AimLong-term pharmacokinetics after supplementation with vitamin D3 or calcifediol (the 25-hydroxyvitamin D3 metabolite) is not well studied. Additionally, it is unclear whether bolus doses of vitamin D3 or calcifediol lead to 25(OH)D3 plasma concentrations considered desirable for fracture prevention (30 ng/mL). We therefore investigated plasma pharmacokinetics of 25(OH)D3 during different vitamin D3 and calcifediol supplementation regimens.MethodsIn this seven-arm, randomized, double-blind, controlled parallel-group study, 35 healthy females aged 50–70 years (5 per group) received 20 μg calcifediol or vitaminD3 daily, 140 μg calcifediol or vitaminD3 weekly, for 15 weeks, or a single bolus of either 140 μg calcifediol, or vitaminD3, or both. 25(OH)D3 plasma concentrations were quantified using LC–MS/MS in 14 clinical visits among all participants.ResultsFor daily (weekly) dosing, the area under the concentration–time curve (AUC0–24h), which is the measure for exposure, was 28% (67%) higher after the first dose of calcifediol than after the first dose of vitamin D3. After 15 weeks, this difference was 123% (178%). All women in the daily and weekly calcifediol groups achieved 25(OH)D3 concentrations > 30 ng/mL (mean, 16.8 days), but only 70% in the vitamin D3 daily or weekly groups reached this concentration (mean, 68.4 days). A single dose of 140 μg calcifediol led to 117% higher 25(OH)D3 AUC0–96h values than 140 μg vitamin D3, while the simultaneous intake of both did not further increase exposure.ConclusionsCalcifediol given daily, weekly, or as a single bolus is about 2–3 times more potent in increasing plasma 25(OH)D3 concentrations than vitamin D3. Plasma 25(OH)D3 concentrations of 30 ng/mL were reached more rapidly and reliably with calcifediol. |
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