Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication |
| |
| Authors: | Masanori Ito Shinji Tanaka Kazuaki Chayama |
| |
| Affiliation: | 1.Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan ; 2.Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan ; 3.Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan |
| |
| Abstract: | The prevalence of gastric cancer after eradication (GCAE) is increasing dramatically in Japan. GCAE has characteristic features, and we must understand these features in endoscopic examinations. Differentiated cancer types were frequently found after eradication and included characteristic endoscopic features such as reddish depression (RD). However, benign RD can be difficult to distinguish from gastric cancer because of histological alterations in the surface structures (nonneoplastic epithelium or epithelium with low-grade atypia [ELA]) as well as multiple appearances of RD. Recently, we clarified similar alterations in genetic mutations between ELA and gastric cancer, suggesting that ELA is derived from gastric cancer. Clinically, submucosal invasive cancer was frequently found in patients after eradication therapy even if they received annual endoscopic surveillance. We can improve the diagnostic ability using image-enhanced endoscopy with magnified observation. (Gut Liver 2021;15:-345) |
| |
| Keywords: | Stomach neoplasms Eradication therapy Helicobacter pylori Reddish depression Epithelium with low-grade atypia |
|
|
