Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography |
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| Institution: | 1. Clinic for Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland;2. Center for Rheumatology and Bone Disease, Klinik Im Park, Zurich, Switzerland;3. Rheumatology Clinic, CHUV, Lausanne, Switzerland;4. Institute of Biomedical Engineering, ETH, University of Zurich, Switzerland;5. Clinic for Masticatory Disorders, Removable Prosthodontics, Geriatric and Special Care Dentistry, Center of Dental Medicine, University of Zurich, Switzerland;1. Army Personnel Research Capability, Army Headquarters, Andover, United Kingdom;2. Department of Occupational Medicine, HQ Army Recruiting and Initial Training Command, Upavon, United Kingdom;3. Extremes Research Group, Bangor University, Bangor, United Kingdom;4. Norwich Medical School, University of East Anglia, Norwich, United Kingdom;5. Norfolk and Norwich University Hospital, Norwich, United Kingdom;1. INSERM UMR 1033, Université de Lyon, France;2. Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands;1. Bone Metabolism Laboratory, Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil;2. Center of Bone diseases - Rheumatology Division, Bone & Joint Department, Lausanne University Hospital, Lausanne, Switzerland;3. Département de Médecine, Service de Rhumatologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Canada;1. Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, THR-1051 Boston, MA, USA;2. United States Army Research Institute of Environmental Medicine, 10 General Greene Ave, Natick, MA, USA;3. Harvard Medical School, 25 Shattuck St., Boston, MA, USA;4. Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, One Overland Street, Boston, MA, USA |
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| Abstract: | This study intended to compare bone density and architecture in three groups of women: young women with anorexia nervosa (AN), an age-matched control group of young women, and healthy late postmenopausal women. Three-dimensional peripheral quantitative high resolution computed-tomography (HR-pQCT) at the ultradistal radius, a technology providing measures of cortical and trabecular bone density and microarchitecture, was performed in the three cohorts. Thirty-six women with AN aged 18–30 years (mean duration of AN: 5.8 years), 83 healthy late postmenopausal women aged 70–81 as well as 30 age-matched healthy young women were assessed. The overall cortical and trabecular bone density (D100), the absolute thickness of the cortical bone (CTh), and the absolute number of trabecules per area (TbN) were significantly lower in AN patients compared with healthy young women. The absolute number of trabecules per area (TbN) in AN and postmenopausal women was similar, but significantly lower than in healthy young women.The comparison between AN patients and post-menopausal women is of interest because the latter reach bone peak mass around the middle of the fertile age span whereas the former usually lose bone before reaching optimal bone density and structure. This study shows that bone mineral density and bone compacta thickness in AN are lower than those in controls but still higher than those in postmenopause. Bone compacta density in AN is similar as in controls. However, bone inner structure in AN is degraded to a similar extent as in postmenopause. This last finding is particularly troubling. |
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