Mortality following the first hip fracture in Norwegian women and men (1999–2008). A NOREPOS study |
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| Institution: | 1. Department of Global Public Health and Primary Care, University of Bergen, Norway;2. Institute of Health and Society, Department of Community Medicine, University of Oslo, Norway;3. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;4. Department of Health and Care Sciences, University of Tromsø, Norway;5. Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia;6. Institute of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway;7. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway;8. Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Norway;9. Department of Obstetrics and Gynecology, St. Olav''s University Hospital, Trondheim, Norway;10. Clinical Institute, Aalborg University, Aalborg, Denmark;11. Clinical Translation and Advanced Education, Garvan Institute of Medical Research, Sydney, NSW, Australia;12. Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia;13. School of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia;1. Department of Anthropology, Pennsylvania State University, University Park, PA, USA;2. Department of Microbiology, New York University School of Medicine, New York, NY, USA;3. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA;1. INSERM UMR 1033, Université de Lyon, France;2. Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands;1. Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA;2. Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, USA;1. Vanderbilt University Medical Center, Department of Orthopaedics, 2200 Children''s Way, Nashville, TN 37232-9565, USA;2. Vanderbilt University Medical Center, Department of Center for Bone Biology, 2200 Children''s Way, Nashville, TN 37232-9565, USA;3. Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, 2200 Children''s Way, Nashville, TN 37232-9565, USA;4. Vanderbilt University Medical Center, Department of Pharmacology, 2200 Children''s Way, Nashville, TN 37232-9565, USA;5. Vanderbilt University Medical Center, Department of Pediatrics, 2200 Children''s Way, Nashville, TN 37232-9565, USA;6. Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan;7. Vanderbilt University Medical Center, Department of Cardio-Oncology, 2200 Children''s Way, Nashville, TN 37232-9565, USA |
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| Abstract: | Hip fractures are associated with increased mortality and their incidence in Norway is one of the highest worldwide. The aim of this nationwide study was to examine short- and long-term mortality after hip fractures, burden of disease (attributable fraction and potential years of life lost), and time trends in mortality compared to the total Norwegian population. Information on incident hip fractures between 1999 and 2008 in all persons aged 50 years and older was collected from Norwegian hospitals. Death and emigration dates of the hip fracture patients were obtained through 31 December 2010. Standardized mortality ratios (SMRs) were calculated and Poisson regression analyses were used for the estimation of time trends in SMRs. Among the 81,867 patients with a first hip fracture, the 1-year excess mortality was 4.6-fold higher in men, and 2.8-fold higher in women compared to the general population. Although the highest excess mortality was observed during the first two weeks post fracture, the excess risk persisted for twelve years. Mortality rates post hip fracture were higher in men compared to women in all age groups studied. In both genders aged 50 years and older, approximately 5% of the total mortality in the population was related to hip fractures. The largest proportion of the potential life-years lost was in the relatively young-old, i.e. less than 80 years. In men, the 1-year absolute mortality rates post hip fracture declined significantly between 1999 and 2008, by contrast, the mortality in women increased significantly relatively to the population mortality. |
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