Transversely isotropic properties of porcine liver tissue: experiments and constitutive modelling |
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Authors: | C Chui E Kobayashi X Chen T Hisada I Sakuma |
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Institution: | (1) Biomedical Precision Engineering Lab, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan;(2) Computational Biomechanics Lab, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan;(3) Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore;(4) Faculty of Medical Sciences, Kyushu University, Tokyo, Japan;(5) Centre for Biomedical Materials Applications and Technology, National University of Singapore, E3-05-23, Engineering Drive 3, Singapore, Singapore, 119260 |
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Abstract: | Knowledge of the biomechanical properties of soft tissue, such as liver, is important in modelling computer aided surgical
procedures. Liver tissue does not bear mechanical loads, and, in numerical simulation research, is typically assumed to be
isotropic. Nevertheless, a typical biological soft tissue is anisotropic. In vitro uniaxial tension and compression experiments
were conducted on porcine cylindrical and cubical liver tissue samples respectively assuming a simplistic architecture of
liver tissue with its constituent lobule and connective tissues components. With the primary axis perpendicular to the cross
sectional surface of samples, the tissue is stiffer with tensile or compressive force in the axial direction compared to that
of the transverse direction. At 20% strain, about twice as much force is required to elongate a longitudinal tissue sample
than that of a transverse sample. Results of the study suggest that liver tissue is transversely isotropic. A combined strain
energy based constitutive equation for transversely isotropic material is proposed. The improved capability of this equation
to model the experimental data compared to its previously disclosed isotropic version suggests that the assumption on the
fourth invariant in the constitutive equation is probably correct and that anisotropy properties of liver tissue should be
considered in surgical simulation. |
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Keywords: | Liver tissue Transversely isotropic hyperelasticity Experiments Constitutive law Tissue modelling |
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