| 抗高血压因子对正常及高血压动物动脉平滑肌Ca~(2+)内流的影响 |
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| 引用本文： | 文允镒,陈孟勤,贾红鹏,吴光玉,周立平,张淑芳.抗高血压因子对正常及高血压动物动脉平滑肌Ca~(2+)内流的影响[J].中国医学科学院学报,1991(2). |
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| 作者姓名： | 文允镒 陈孟勤 贾红鹏 吴光玉 周立平 张淑芳 |
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| 作者单位： | 中国医学科学院基础医学研究所 北京
(文允镒，陈孟勤，贾红鹏，吴光玉，周立平)，中国医学科学院基础医学研究所 北京(张淑芳) |
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| 摘 要： | 通过实验观察到从自发性高血压大鼠(SHR)红细胞提取的抗高血压因子(AHF)可以明显抑制SHR血管平滑肌(VSM)Ca~(2+)内流,呈剂量依赖关系。而对正常血压大鼠(WKY)无影响。这种抑制作用及与剂量的关系在肠系膜动脉比主动脉更明显。结果表明,AHF的降压作用可能与抑制VSM Ca~(2+)内流有关。
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| 关 键 词： | 自发性高血压大鼠 红细胞抗高血压因子 Ca~(2+)内流 |
Effect of Antihypertensive Factor on Ca2+ Influx in Arterial Smooth Muscle from Normotensive and Spontaneously Hypertensive Rats |
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| Wen Yunyi,et al.Effect of Antihypertensive Factor on Ca2+ Influx in Arterial Smooth Muscle from Normotensive and Spontaneously Hypertensive Rats[J].Acta Academiae Medicinae Sinicae,1991(2). |
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| Authors: | Wen Yunyi |
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| Abstract: | Aorta segments(A) and mesenteric arteries (MA) from stroke prone spontaneously hypertensive rats (SHRsp) and control Wistar Kyoto rats (WKY) were used in the present study to assess the effect of AHF on Ca2+ influx in vascular smooth muscle (VSM). The results indicated that Ca2+ influx in VSM of SHRsp was much higher than that of WKY rats (P<0.05). AHF at 10-7, 10-6 and 10-5 g/ml can significantly inhibit Ca2+ influx in a dose-dependent manner in VSM of both A and MA (P<0.05 and <0.0l). The suppression effect of AHF on Ca2+ influx and the concentration-dependent relationship were more obvious in MA than in A. The Ca2+ influx in VSM of WKY rats was unaffected by administration of AHF. |
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| Keywords: | spontaneouly hypertensive rat antihypertensive factor Ca2f influx |
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