宫保散及联合LEEP治疗CIN合并HPV感染的疗效分析

目的分析宫保散在临床治疗宫颈癌前病变(CIN)并发HPV感染的疗效及观察联合LEEP治疗宫颈癌前病变的临床疗效。方法选取于我院妇科门诊于2012年1月—2014年1月期间就诊的120例宫颈癌前病变并发HPV感染的患者。以数字法随机分成观察组(60例)和对照组(60例)。观察组施以宫保散局部外涂联合LEEP技术治疗;对照组则单纯的施以宫保散局部外涂治疗。分析观察组治疗后的影响及对比两组的疗效。结果宫保散可提高CINⅠ、CINⅡ、CIN3患者的转阴率:治疗转阴率分别为81.82%,41.94%及16.67%,且对CINⅠ并发HPV感染转阴率疗效最佳;达81.82%;用药时间较长的治愈率较高:用药1~2及2~3及3~4个疗程的治愈率分别为65%,76.67%,85%;宫保散联合LEEP治疗对CIN并发HPV感染治疗疗效明显高于单纯的宫保散疗效:疗效分别为100%和91.67%。结论宫保散联合LEEP手术在治疗CIN并发HPV感染不仅治疗疗程及操作简单,病人依从性好,治疗创伤小而且费用低,临床效果肯定,不容易复发。大大提高了对CIN并发HPV感染的治疗效果。

A comparison of therapeutic effects between Kung powder and Kung powder combined with LEEP on treating CIN as-sociated with HPV-infection

Objective The study is designed to evaluate the therapeutic effect of Kung powder as a clinical treatment for cervical intraepithelial neoplasia （aka.CIN）complicated with HPV infection and observe the influence on curative effect when Loop Electrosurgical Excision Procedure （aka.LEEP）is combined within the therapeutic regimens. Methods 1 20 ca-ses were selected from the patients who are diagnosed as CIN complicated with HPV infection in outpatient department of depart-ment of gynecology of our hospital during January 201 2 to January 201 4.Based on digital method,patients are randomly divided into two groups：observation group （60 cases）and control group （60 cases）.In observer group we combined the external use of Kung powder with LEEP during treatment,while in control group patients were treated only with the external use of Kung powder.Then we analyzed and evaluated the therapeutic effect of both groups with a statistics analysis system. Results Kung powder is capable of improving the negative conversion rate of CIN Ⅰ,CIN Ⅱ,CIN3 patients,in which the negative conversion rate of CIN Ⅰ complicated with HPV infection rates the highest;Longer treatment period leads to higher cure rate：the cure rates of treatments lasting 1 -2,2-3 and 3-4 courses are 65%,76.67% and 85%;The treatment combining the external use of Kung powder with LEEP for CIN complicated with HPV infection （cure rate 1 00%）showed significantly more satisfying curative effect than the treatment using Kung powder externally along （cure rate 91 .67%）. Conclusion Kung powder combining LEEP in the treatment regimen produces has easier operation,less trauma,lower costing,better clinical effect and less recurrence,which greatly improved the curative effect of CIN complicated with HPV infection.