| 乙肝病毒感染者外周血中CD4~+Foxp3~+T细胞亚群的表达及临床意义 |
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| 引用本文： | 谭雨龙,张绪清,张梦军,傅晓岚,游建平,王莉,吴玉章.乙肝病毒感染者外周血中CD4~+Foxp3~+T细胞亚群的表达及临床意义[J].免疫学杂志,2010(5). |
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| 作者姓名： | 谭雨龙 张绪清 张梦军 傅晓岚 游建平 王莉 吴玉章 |
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| 作者单位： | 第三军医大学免疫学教研室;西南医院传染科; |
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| 基金项目： | 国家自然科学基金面上项目(30872352);;国家重大新药创制专项课题(2009ZX09503-005) |
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| 摘 要： | 目的研究外周血中3个CD4~+Foxp3~+T细胞亚群在乙肝病毒感染者外周血中频率及其可能的临床意义。方法分离来自无症状携带者(AsC)、慢性乙型肝炎患者(CHB)以及健康对照(Health)的外周血单个核细胞(PBMC),用流式细胞术分析PBMC中3个CD4~+Foxp3~+T细胞亚群占CD4~+T细胞的比例,并分析其与临床参数间的相关性,同时将CD4~+CD25~+Foxp3~+Treg作对比分析。结果CD4~+CD45RA~+Foxp3~(lo)(静息态Treg)频率在各实验组间无显著差别;CD4~+CD45RA~-Foxp3~(lo)(非Treg)频率在CHB组和AsC组间无明显差别,但两组相对Health组明显升高;CHB组CD4~+CD45RA~-Foxp3~(hi)(活动态Treg)明显高于AsC组和Health组。在CHB和AsC病例中活动态Treg与HBV病毒载量,HBeAg状态均无显著相关性。在CHB病例中活动态Treg与ALT水平不相关。结论相当比例的不具抑制功能的Foxp3~+T细胞可能混杂在CD4~+CD25~+Foxp3~+Treg的分析中,因此活动态Treg比CD4~+CD25~...
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| 关 键 词： | 慢性乙型肝炎 活动态Treg 流式细胞术 |
Expression and clinical significance of circulating CD4~+Foxp3~+T cell subsets in patients with hepatitis B |
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| TAN Yulong,ZHANG Xuqing,ZHANG Mengjun,FU Xiaolan,You Jianping,WANG Li,WU Yuzhang Immunology Institute of PLA,Third Military Medical University,Chongqing ,China.Expression and clinical significance of circulating CD4~+Foxp3~+T cell subsets in patients with hepatitis B[J].Immunological Journal,2010(5). |
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| Authors: | TAN Yulong ZHANG Xuqing ZHANG Mengjun FU Xiaolan You Jianping WANG Li WU Yuzhang Immunology Institute of PLA Third Military Medical University Chongqing China |
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| Institution: | TAN Yulong,ZHANG Xuqing,ZHANG Mengjun,FU Xiaolan,You Jianping,WANG Li,WU Yuzhang Immunology Institute of PLA,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Regulatory T cell may be involved in chronic persistence of hepatitis B virus infection.We investigated the frequency and clinical correlation of three CD4~+Foxp3~+T cell subsets in the peripheral blood of chronic HBV patients(CHB),asymptomatic HBV carriers(AsC),and healthy controls,in comparison with CD4~+CD25~+Foxp3~+Tregs.The frequency of CD4~+CD45RA~+Foxp3~(lo) T cells(resting Treg) didn't show significant difference among the subjects.Patients with CHB or AsC exhibited a significantly higher frequency ... |
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| Keywords: | Chronic hepatitis B Activated Treg Flow cytometry |
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