高同型半胱氨酸血症对2型 糖尿病交感神经功能状态的影响 |
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引用本文: | 王素红,张哲成,刘娜,朱炬,张静.高同型半胱氨酸血症对2型 糖尿病交感神经功能状态的影响[J].天津医药,2012,40(6):547-549. |
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作者姓名: | 王素红 张哲成 刘娜 朱炬 张静 |
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作者单位: | 1. 天津市医科大学第三中心医院临床学院2. 天津市第三中心医院3. 第三中心医院神经内科4. 天津市第三中心医院神经内科 |
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摘 要: | 摘要 目的:研究高同型半胱氨酸血症(Hhcy)对2型糖尿病(DM)交感神经功能状态的影响。方法:选取2型糖尿病Hhcy患者22例并与22例2型糖尿病非Hhcy患者作为对照,采用丹麦Keypoint.net肌电图仪通过皮肤交感反射(SSR)检测技术,对2组患者进行四肢SSR测定,记录并比较2组患者SSR波平均潜伏期、波幅及同侧上下肢SSR相对比值差异。结果:Hhcy组和非Hhcy组SSR潜伏期上肢分别为(1593.11±149.85) ms、(1539.75±149.22 )ms(P>0.05);下肢分别为(2795.86±415.24) ms、(2617.93±327.61) ms(P<0.05)。Hhcy组和非Hhcy组SSR波幅上肢分别为(1.03±0.38)mV、(1.22±0.30)mV(P<0.01);下肢分别为(0.28±0.17) mV、(0.38±0.15)mV,(P<0.01)。2组同侧上下肢SSR波幅相对比值Hhcy组比非Hhcy组增高(P<0.001),而同侧上下肢SSR潜伏期相对比值2组差异无统计学意义。结论:Hhcy可以加重2型DM交感神经损害程度,且有长度依赖性特点,而SSR检测是简单可行的手段。
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关 键 词: | 高半胱氨酸 糖尿病 2型 糖尿病神经病变 交感神经系统 四肢 皮肤交感反射 |
收稿时间: | 2011-10-25 |
修稿时间: | 2012-01-31 |
Affection of hyperhomocysteinemia on sympathetic nervous fanction of 2 type diabetic mmellitus |
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Abstract: | Affection of hyperhomocysteinemia on sympathetic nervous
function of 2 type diabetic mellitus
WANG suhong, ZHANG zhecheng, LIU na, ZHU ju, ZHANG jing
Department of Neurology, The Third Central Clinical College of Tianjin Medical University, Tianjin 300170,China
Abstrict Object:To investigate affection of hyperhomocysteinemia(Hhcy)on sympathetic nervous function of 2 type diabetic mellitus(DM)by detection of sympathetic skin reflex(SSR).Methods:44 patients with 2 type DM were divided two groups: Hhcy group(n=22) and NHhcy group(n=22).Detection of SSR were given to four limbs of all patients, record and compare average latencies、amplitudes and ratios of upper to lower limbs. Results: SSR upper limbs latencies in Hhcy group (1593.11±149.85)ms] were prolonged than that in NHhcy (1539.75±149.22)ms](p>0.05).SSR lower limbs latencies in Hhcy group (2795.86±415.24)ms] were prolonged than that in NHhcy group (2617.93±327.61)ms](p<0.05). SSR upper limbs amplitudes in Hhcy group (1.03±0.38)mv] were reduced than that in NHhcy group (1.22±0.30mv) (p<0.01).SSR lower limbs amplitudes in Hhcy group (0.28±0.17)mv]were reduced than that in NHhcy group (0.38±0.15)mv](p<0.01). Amplitude ratios of upper to lower limbs in Hhcy group were higher than that in NHhcy group, z=3.5176, p<0.001;but latency ratios of upper to lower limbs between 2 groups had not statistical significance。Conclusion:Hhcy may increase the damage to sympathetic nervous of 2 type DM; it has features of Length dependence, and detection of SSR provides Simple and feasible technique. |
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Keywords: | homocysteinediabetes mellitus type 2diabetic neuropathiessympathetic nervous systemextremitiessympathetic skin reflex |
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