胃肠激素与功能性消化不良患者胃肠动力障碍的关系

目的　探讨胃肠激素与功能性消化不良 (FD)患者胃肠动力障碍的关系。方法　对 5 4例FD患者进行胃排空检查 ,根据结果将其分为胃排空延缓FD组和胃排空正常FD组 ,另以 17例正常人作为对照组。用放免法测定受试者空腹和餐后血浆NT、MTL、Gas、SS含量。结果　胃排空延缓FD组空腹和餐后血浆NT含量、餐后血浆Gas含量明显高于正常人及胃排空正常FD组 ,空腹和餐后血浆MTL含量则明显低于另外两组 ,而空腹和餐后血浆SS与另外两组比较差异无统计学意义。结论　FD患者胃肠动力障碍与NT、MTL、Gas密切相关 ;NT、MTL、Gas在FD的发病机制中可能有一定作用。

RELATIONSHIP BETWEEN GASTROINTESTINAL HORMONES AND GASTROINTESTINAL DYSMYOTONIA IN FUNCTIONAL DYSPEPSIA PATIENTS

Objective To study the relationship between gastrointestinal hormones and gastric emptying in functional dyspepsia (FD) patients. Methods Gastric emptying was assessed with solid radiopaque markers in 54 patients with functional dyspepsia, and then all patients were divided into two groups, one with delayed gastric emptying and the other with normal gastric emptying. 17 healthy volunteers served as normal control group. The plasma NT, MTL, Gas and SS levels (fasting and 30 minutes after meal) were measured by radioimmunoassay (RIA). Results The fasting and postprandial plasma NT levels and the postprandial plasma Gas level were significantly higher in FD group with delayed gastric emptying than those in FD group with normal gastric emptying and in normal control group. The MTL levels in fasting and postprandial plasma were significantly lower in FD group with delayed gastric emptying than those in FD group with normal gastric emptying and in normal control group. The plasma SS levels did not show differences among three groups. Conclusion Gastrointestinal dysmyotonia is closely related to NT, MTL and Gas. NT, MTL and Gas may be important in the pathogenesis of FD.