| 再生障碍性贫血患者骨髓和外周血中FL水平的测定及意义 |
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| 引用本文： | 季玉红,钱绩虎,傅晋翔,张学光.再生障碍性贫血患者骨髓和外周血中FL水平的测定及意义[J].南通医学院学报,2002,22(4):376-377. |
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| 作者姓名： | 季玉红 钱绩虎 傅晋翔 张学光 |
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| 作者单位： | 1. 南通医学院微生物学教研室,南通,226001
2. 苏州大学生物技术研究所 |
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| 基金项目： | 国际原子能机构资助项目 (CRP/ 0 2 5 ) |
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| 摘 要： | 目的 :测定再生障碍性贫血 (AA)患者骨髓 (BM)和外周血 (PB)中酪氨酸激酶受体 3的配体 (FL)的水平 ,并探讨其意义。方法 :用常规 EL ISA法检测 16例再障患者骨髓和外周血中 FL、s Fas L和 IL - 2的水平。结果 :再障患者骨髓和外周血中 FL 水平显著升高 ,为正常对照的 2 0倍以上 (P<0 .0 1)。再障患者骨髓及外周血中 s Fas L、IL- 2含量也明显高于正常对照组 (P <0 .0 1)。结论 :再障患者骨髓和外周血中 FL、s Fas L、IL - 2含量与患者疾病的严重程度呈负相关。
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| 关 键 词： | 骨髓 外周血 再生障碍性贫血 酪氨酸激酶受体3 配体 测定 |
| 文章编号： | 1000-2057(2002)04-0376-02 |
| 修稿时间： | 2002年9月3日 |
DETECTION OF FLT3-LIGAND LEVEL IN THE BONE MARROW AND PERIPHERAL BLOOD OF THE PATIENTS WITH APLASTIC ANEMIA AND ITS SIGNIFICANCE |
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| JI Yuhong,QIAN Jihu,FU Jinxiang,et al.DETECTION OF FLT3-LIGAND LEVEL IN THE BONE MARROW AND PERIPHERAL BLOOD OF THE PATIENTS WITH APLASTIC ANEMIA AND ITS SIGNIFICANCE[J].ACTA Academiae Medicinae Nantong,2002,22(4):376-377. |
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| Authors: | JI Yuhong QIAN Jihu FU Jinxiang |
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| Institution: | JI Yuhong,QIAN Jihu,1FU Jinxiang,et al |
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| Abstract: | Objective:To investigate Flt3-ligand level in the bone marrow(BM) and peripheral blood(PB) of the patients with aplastic anemia (AA) and its significance.Methods: The levels of FL in the BM and PB from 16 Patients with AA were detected by ELISA.Results:The levels of FL, sFasL, IL-2 increased in patients BM and PB with AA. The level of FL was more significant (P<0.01).Conclusion:The level of FL in patients BM and PB with AA was negatively correlated with the course of AA. |
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| Keywords: | Aplastic Anemia Flt3-L Ligand |
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