我院291例药品不良反应报告描述性分析

目的：研究我院药品不良反应（ADR）发生特点，掌握ADR监测工作现状，规避临床用药风险。方法：以Excel电子表格形式从国家ADR监测网络下载我院2007年12月1日-2008年11月30日ADR报告表，对有关数据进行适当转换后，进行统计分析。结果：291份ADR报告中抗感染药物所占比例最大，其次为抗肿瘤药和营养药；ADR累及器官或系统主要为全身性损害、消化系统损害、皮肤及其附件损害；240例（82．5％）ADR由静脉给药途径所致；新的、严重的报告共涉及22种药品。结论：应重视对新的、严重的ADR报告分析，及时筛选信号、展开调研、发布预警，形成有效信息流，降低临床用药风险。

Analysis of 291 ADR Reports in Our Hospital

Objective： To investigate the characteristics of adverse drug reactions （ADRs） in our hospital, and master the present situation of ADR monitoring to avoid the drug risk in clinic. Methods： ADR reports in our hospital from December 1, 2007 to November 30, 2008 were downloaded from national ADR monitoring network in terms of Excel form. The related data formats were converted and analyzed statistically. Results： Of the 291 ADR cases, anti-infective agents ranked the first and followed by the antitumor agents and the nutritional drugs. The lesions of systems or organs involved in ADRs were the systemic disorders, gastrointestinal system disorders and skin and appendage damages. 240 ADR cases （82.5%） were induced by the intravenous drip. 22 Categories of medicines were involved in the new and serious ADR reports. Conclusion： It should be paid more attention to the new and serious ADR reports, extracting signal, expanding safe research, promulgating precaution to decrease the drug risk.