| 腺病毒肺炎患儿染色体畸变追踪观察 |
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| 引用本文： | 卢尧,何兰,金惠敏. 腺病毒肺炎患儿染色体畸变追踪观察[J]. 吉林大学学报(医学版), 1988, 0(4) |
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| 作者姓名： | 卢尧 何兰 金惠敏 |
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| 作者单位： | 白求恩医科大学医学遗传学教研室(卢尧)，白求恩医科大学第一临床学院小儿科(何兰)，白求恩医科大学第一临床学院小儿科(金惠敏) |
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| 摘 要： | 本文对8例罹患过3型、7型腺病毒肺炎的婴幼儿染色体畸变情况追踪观察2～4年。对此8例共分析外周血淋巴细胞400个中期分裂相,发现108个畸变,总畸变率为27％。结构畸变类型有单体缺失、单体断裂和染色体断裂,以单体缺失为主。没有发现染色体数目的改变。
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| 关 键 词： | 腺病毒肺炎 染色体畸变 |
Observation on chromosome aberration in peripheral blood of 8 infants due to adenovirus pneumonia |
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| Lu Yao,He Lan and Jin Huimin. Observation on chromosome aberration in peripheral blood of 8 infants due to adenovirus pneumonia[J]. Journal of Jilin University: Med Ed, 1988, 0(4) |
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| Authors: | Lu Yao He Lan Jin Huimin |
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| Abstract: | Eight infants with adenoviral pneumonia were examined for chromosome aberration for 2-4 years. During the period of observation, all these infants completely recovered. Conventional analyses with light microscope (x 100) were carried out.The results were. ( 1 ) Chromosomal structural berration was found in the examined cells, the aberrant rate being 26%. (2) Types of structural aberration included chromatid deletion, chromatid breakage and chromosomal breakage, with the chromatid deletion being the major aberration. In addition, chromosomal structural slack and chromosomal adhesion were found, too. (3) No change in the chromosomal number was found. (4) Compared with the results obtained from these patients before recovery, the frequency of chromosome-aberration is much higher, and the ratio of chromatid deletion to chromatid breakage is higher, too. |
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| Keywords: | Chromosome aberration Adenoviral pneumonia Infants |
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