| 血液细胞重编程为诱导性多能干细胞的研究进展 |
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| 引用本文： | 张玥 武玢 宮甜甜 雷蕾 单智焱. 血液细胞重编程为诱导性多能干细胞的研究进展[J]. 解剖学报, 2015, 46(6): 852-856. DOI: 10.16098/j.issn.0529-1356.2015.06.022 |
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| 作者姓名： | 张玥 武玢 宮甜甜 雷蕾 单智焱 |
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| 作者单位： | 哈尔滨医科大学组织学与胚胎学教研室，哈尔滨 150081 |
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| 摘 要： | 诱导性多能干细胞（iPSCs)技术能够将已分化的体细胞反转为多能细胞，因其不存在伦理、排斥等问题，在再生医学领域具有广阔的应用前景。尽管已经建立了来源于多种体细胞的诱导性多能干细胞，但是能实际应用于临床、取材便利、诱导安全的供体来源仍然具有局限性。我们从血液细胞作为供体细胞进行重编程的特点、优势及应用等方面进行了综述。
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| 关 键 词： | 血液细胞 诱导性多能干细胞 重编程 应用 |
| 收稿时间： | 2015-04-02 |
| 修稿时间： | 2015-05-29 |
Progress of blood cells reprogramming to induced pluripotent stem cells |
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| ZHANG Yue WU Bin GONG Tian-tian LEI Lei SHAN Zhi-yan. Progress of blood cells reprogramming to induced pluripotent stem cells[J]. Acta Anatomica Sinica, 2015, 46(6): 852-856. DOI: 10.16098/j.issn.0529-1356.2015.06.022 |
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| Authors: | ZHANG Yue WU Bin GONG Tian-tian LEI Lei SHAN Zhi-yan |
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| Affiliation: | Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China |
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| Abstract: | Induced pluripotent stem cells (iPSCs) technology can revert differentiated cells to pluripotent cells and avoid the limitation such as ethics, immunerejection. It has broad applications in the field of regenerative medicine. Although induced pluripotent stem cells have already set up for all sorts of donor cells, the application in clinical facilities and induction of donor origin still has various limitations. In this review, we discuss the characteristics, advantages and applications of utilizing blood cells as donor cells for reprogramming, providing a theoretical basis for the ultimate applications of induced pluripotent stem cells in clinical studies. |
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| Keywords: | Blood cell Induced pluripotent stem cell Reprogramming Application |
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