甲壳素-聚己内酯复合接骨板的生物吸收率研究

目的 :了解甲壳素 聚己内酯复合可吸收接骨板在动物体内的降解速度及随时间的变化。　方法 :在实验组中 ,将甲壳素 聚己内酯复合可吸收接骨板及螺钉 ,包埋于 2 8只新西兰白兔右胫骨中段 ;在对照组中 ,选择 8只新西兰白兔 ,于相应部位植入金属钢板。实验组动物于手术后 2、4、6、8、12、2 4、36周处死。对照组于术后 4、8周时分别处死。实验组的动物均行生物吸收率 (BAR)测定。　结果 :甲壳素 聚己内酯复合接骨板及螺钉在动物体内可降解。 4周组吸收率为 4 .36 % ,6周组为 7.13% ,12周组为 12 .8% ,36周组为 16 .37%。　结论 :甲壳素 聚己内酯复合接骨板在体内可吸收 ,随时间的延长 ,生物吸收率逐渐增加 ,但不成线性关系

The biological absorb rate of chitin-polycaprolactone bone plate

Objectives:To investigate the degradation speeds of reabsorbable bone plates by animal experiment. Methods:In the test group, the reabsorbable bone plates and bolts, which were made of chitin and polycaprolactone, were embedded in the middle region of the right tibia of rabbit. The follow up times were 2,4,6,8,12,24 and 36 weeks after operation. In the control group, the reabsorbable bone plates and bolts were replaced with metal bone plates and bolts. The follow up times were 4,8 weeks, after which the biologic absorb rate(BAR) were estimated. Results:The chitin and polycaprolactone bone plates and bolts could degrade. The BAR was 4.36% by 4 weeks, 7.13 % by 6 weeks,12.8% by 12 weeks, and 16.37% by 36 weeks. Conclusions:The chitin and ploycaprolactone bone plates and bolts was reabsorbable, the BAR was increased with time, but the relationship was not linear.