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| GSTT1及CYP1A1基因多态性与肺癌易感性关系 | |
| 引用本文： | 白图雅,常福厚,王敏杰,王光,张硕.GSTT1及CYP1A1基因多态性与肺癌易感性关系[J].中国公共卫生,2011,27(6). |
| 作者姓名： | 白图雅 常福厚 王敏杰 王光 张硕 |
| 作者单位： | 1. 内蒙古医学院药学院药理教研室,内蒙古,呼和浩特010059 2. 内蒙古医学院基础医学院药理教研室 3. 内蒙古医学院附属医院检验科 4. 中国药科大学药学院 |
| 基金项目： | 国家自然科学基金，内蒙古自治区科技厅项目，内蒙古医学院博士启动基金 |
| 摘 要： | 目的 探讨细胞色素P4501A1(CYP1A1)和谷胱甘肽硫转移酶T1(GSTT1)基因多态性与肺癌易感性的关系.方法 用等位特异性PCR(AS-PCR)及多重PCR技术分析106例肺癌患者和250名健康人的CYP1A1、GSTT1基因多态性、基因型分布频率和交互作用.结果 携带CYP1A1(Val/Val)/GSTT1(-)基因型的人患肺癌的风险明显增加(P=0.025);吸烟与肺癌易感性有关(P=0.037),吸烟者患肺癌的风险明显增加(OR=1.628.95%CI=1.028～2.577);携带CYP1A1(Val/Val)基因的吸烟者较携带CYP1A1(Ile/Ile)基因型的不吸烟者易患肺癌(P=0.033);携带GSTT1(-)的吸烟者患肺癌的风险明显增加(P=0.045).结论 CYP1A1突变型和GSTT1(-)基因型是肺癌的可疑易患因素,二者对肺癌的发生有协同作用,但单独携带CYP1A1突变型或GSTT1(-)基因型肺癌易感性差异无统计学意义,吸烟与肺癌易感性有关;CYP1A1突变型、GSTT1(-)基因型与吸烟在肺癌的发生上有相互促进作用. |
| 关 键 词： | 细胞色素P4501A1 谷胱甘肽硫转移酶T1 吸烟 基因多态性 肺癌易感性 |
Relationship between GSTT1 and CYP1A1 genetic polymorphisms and lung cancer susceptibility |
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| BAI Tu-ya,CHANG Fu-hou,WANG Min-jie,et al..Relationship between GSTT1 and CYP1A1 genetic polymorphisms and lung cancer susceptibility[J].Chinese Journal of Public Health,2011,27(6). | |
| Authors: | BAI Tu-ya CHANG Fu-hou WANG Min-jie |
| Institution: | BAI Tu-ya,CHANG Fu-hou,WANG Min-jie,et al.Department of Pharmacology,School of Pharmacy,Inner Mongolia Medical College(Hohhot 010059,China) |
| Abstract: | Objective To explore the susceptibility of lung cancer in relation to cytochrome P4501A1A(CYP1A1) and glutathione S-transferase theta1(GSTT1) genetic polymorphisms.Methods CYP1A1 and GSTT1 genetic polymorphisms were determined with allele specific polymerase chain reaction(AS-PCR) and multiplex PCR in 106 lung cancer patients and 250 healthy people.Results The individuals who carried with CYP1A1(Val/Val)/GSTT1(-) had a high risk of lung cancer(P=0.025).Statistical tests showed that susceptibility to lung ca... |
| Keywords: | CYP1A1 GSTT1 smoking gene polymorphism lung cancer susceptibility |
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