| HIV抗病毒治疗者病毒抑制失败影响因素及耐药 |
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| 引用本文： | 郑本锋,刘宏伟,袁源,刘春华,王哲,杨利婷,邢辉,阮玉华,邵一鸣.HIV抗病毒治疗者病毒抑制失败影响因素及耐药[J].中国公共卫生,2011,27(6). |
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| 作者姓名： | 郑本锋 刘宏伟 袁源 刘春华 王哲 杨利婷 邢辉 阮玉华 邵一鸣 |
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| 作者单位： | 1. 中国疾病预防控制中心性病艾滋病预防控制中心病毒免疫室,北京,100050
2. 河南省疾病预防控制中心性病艾滋病预防控制研究所 |
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| 基金项目： | 国家"十一五"重大专项，加拿大国际发展署，河南省科技攻关重点项目 |
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| 摘 要： | 目的 了解抗病毒治疗者病毒抑制失败影响因素和耐药状况.方法 2009年8月在河南省西华县整群抽取接受抗病毒治疗者371例,进行基本情况和抗病毒治疗相关因素问卷调查,同时抽取静脉血进行病毒载量检测,对病毒载量＞1 000拷贝/mL的血液样本采用逆转录-套式聚合酶链反应(RT-nested PCR)方法扩增HIV-1 POL区基因,进行耐药基因型分析.结果 371例中,病毒抑制失败87例,失败率为23.5%;多因素Logistic回归分析结果显不,男性(OR=1.8,95%CI=1.1～3.1,P=0.026 4)、最近1个月有漏服药物(OR=2.3,95%CI=1.2～4.2,P=0.009 2)和现治疗方案为早期一线治疗方案(OR=2.1,95%CI=1.2～3.9,P=0.012 4)与病毒抑制失败率的关系有统计学意义;病毒抑制失败者的耐药率为63.2%(55/87),其中非核苷类药物和核苷类药物的耐药率分别为63.2%(55/87)和49.3%(43/87),未检测到对蛋白酶类药物的耐药.结论 抗病毒治疗人群中病毒抑制失败率和耐药突变率较高,服药依从性是主要影响因素.
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| 关 键 词： | 艾滋病 人免疫缺陷病毒(HIV) 抗病毒治疗 病毒抑制 依从性 |
Virological suppression failure and drug resistance in HIV-infected patients receiving antiretroviral therapy in Xihua county,Henan province |
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| ZHENG Ben-feng,LIU Hong-wei,YUAN Yuan,et al..Virological suppression failure and drug resistance in HIV-infected patients receiving antiretroviral therapy in Xihua county,Henan province[J].Chinese Journal of Public Health,2011,27(6). |
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| Authors: | ZHENG Ben-feng LIU Hong-wei YUAN Yuan |
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| Institution: | ZHENG Ben-feng,LIU Hong-wei,YUAN Yuan,et al.National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention(Beijing 100050,China) |
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| Abstract: | Objective To study virological suppression failure and drug resistance among HIV-infected patients receiving antiretroviral therapy in Xihua county,Henan province.Methods In August 2009,participants with HIV-infection and receiving antivretroviral therapy(ART) were investigated to collect information on socio-demographics and treatments in Xihua county.Blood samples were collected for viral load test and genotypic resistance was determined in those with a viral load of >1 000 copies/ml,and the HIV pol was a... |
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| Keywords: | AIDS HIV antiretroviral therapy virological suppresion adherence |
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