| 酵母锌与姜黄素联合对酒精性肝损伤保护作用 |
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| 引用本文： | 张晓畅,包巍,荣爽,郝丽萍,姚平,刘烈刚. 酵母锌与姜黄素联合对酒精性肝损伤保护作用[J]. 中国公共卫生, 2011, 27(6) |
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| 作者姓名： | 张晓畅 包巍 荣爽 郝丽萍 姚平 刘烈刚 |
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| 作者单位： | 华中科技大学同济医学院公共卫生学院,湖北,武汉,430030 |
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| 基金项目： | 教育部新世纪优秀人才支持计划，华中科技大学研究生科技创新基金 |
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| 摘 要： | 目的 研究酵母锌与姜黄素的联合作用对酒精性肝损伤的干预效果,为酒精性肝病的预防和治疗提供科学依据.方法 将实验小鼠随机分为正常对照、酒精对照、姜黄素+低、高剂量酵母锌4组,梯度酒精暴露6周造酒精肝损伤模型,同时分别给予低、高剂量(2.5、10 mg/kg)酵母锌联合姜黄素(75 mg/kg)灌胃干预.测定血清丙氨酸转氨酶(ALT)、天冬氨酸转移酶(AST)水平,制作肝组织病理切片并测定肝组织总抗氧化能力(T-AOC)、丙二醛(MDA)、还原型谷胱甘肽(GSH)、谷胱甘肽硫转移酶(GST)、谷胱甘肽过氧化物酶(GSH-PX)含量.结果 姜黄素+低、高剂量酵母锌组ALT活力、MDA含量分别为(34.11±26.04)、(41.74±32.75)U/L和(0.99±0.19)、(0.97±0.25)nmol/mg prot,明显低于酒精对照组(81.54±37.56)U/L和(1.32±0.22)nmol/mg prot(P＜0.05);姜黄素+高剂量酵母锌组GSH、GST、GSH-PX值分别为(1.03±0.15)、(13.84±2.72)、(37.56±4.67)mg/g prot,高于酒精对照组(P＜0.05).结论 酵母锌与姜黄素联合对慢性酒精肝损伤具有良好的保护作用,其防护效应可能与其减轻氧化损伤有关.
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| 关 键 词： | 酵母锌 姜黄素 酒精 肝损伤 氧化应激 |
Synergic effect of curcumin and zinc-enriched yeast on chronic alcoholic liver injury in mice |
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| ZHANG Xiao-chang,BAO Wei,RONG Shuang,et al.. Synergic effect of curcumin and zinc-enriched yeast on chronic alcoholic liver injury in mice[J]. Chinese Journal of Public Health, 2011, 27(6) |
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| Authors: | ZHANG Xiao-chang BAO Wei RONG Shuang et al. |
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| Affiliation: | ZHANG Xiao-chang,BAO Wei,RONG Shuang,et al.School of Public Health,Tongji Medical College,Huazhong University of Science and Technology(Wuhan 430030,China) |
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| Abstract: | Objective To study the synergic effect of curcumin and zinc-enriched yeast on chronic alcohol-induced liver injury,and to provide scientific evidence for the prevention and treatment of alcoholic liver disease.Methods Balb/c mice were randomly divided into 4 groups:normal control,ethanol control,curcumin+low dose zinc-enriched yeast,and curcumin + high dose zinc-enriched yeast group.The chronic alcoholic liver damage model was established with gradient dose of ethanol exposure for 6 weeks.Mice in curcumin +... |
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| Keywords: | zinc-enriched yeast curcumin alcohol liver injury oxidative stress |
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