3.0T MR动态增强成像在前列腺癌诊断中的应用研究

目的 3.0T MR动态增强成像(MR DCE-MRI)在前列腺癌诊断中的应用研究。方法回顾性分析我院2013年5月至2015年5月经穿刺活检病理证实的80例前列腺疾病患者的临床资料,其中前列腺癌50例,前列腺增生30例,均行DCE-MRI与3.0T MR扩散加权成像(DWI)检查,采用DCE-MRI诊断前列腺癌与前列腺增生,并分析两者的平均达峰时间(Tmax)、最大增强斜率(MSI)及信号增强率(SER)。比较DCE-MRI与DWI对前列腺癌诊断的敏感度、特异度及准确度。结果 50例前列腺癌患者中,32例为前列腺癌,18例为中央区癌。前列腺癌Tmax为(69068.34±18005)ms、MSI为(216.02±43.24)、SER为(1 2 2.0 5±1 7.3 4)。前列腺增生Tmax为(83012.56±24352.19)ms、MSI为(1 8 7.2 6±2 9.3 5)、SER为(108.37±11.98)。前列腺癌Tmax早于前列腺增生、MSI、SER较前列腺增生高,有统计学意义(P0.05)。DCE-MRI对前列腺癌诊断的敏感度62.00%、特异度90.00%及准确度82.00%;T2W1对前列腺癌诊断的敏感度71.00%、特异度84.00%及准确度76.00%。两者对前列腺癌诊断的敏感度、特异度及准确度比较均无统计学意义(P0.05)。结论 DCE-MRI与DWI均可用于诊断前列腺癌,在前列腺病变中各具有特征性表现.具有较好的临床应用效果。

Application of 3.0T Dynamic Contrast-Enhanced MR Imaging in the Diagnosis of Prostate Cancer

Objective To study the application of 3.0T dynamic contrast-enhanced MR imaging (MR DCE-MRI) in the diagnosis of prostate cancer.Methods The clinical data of 80 patients with biopsy pathologically confirmed prostate diseases who were admitted iu our hospital between May 2013 and May 2015 were analyzed retrospectively.Among them,there were 50 cases with prostate cancer and 30 cases with benign prostatic hyperplasia.All patients underwent DCE-MRI and 3.0T MR diffusion weighted imaging (DWI) examination.DCE-MRI was used to diagnose prostate cancer and benign prostatic hyperplasia.The mean time to peak (Tmax),maximum slope of increase (MSI) and signal enhancement ratio (SER) were analyzed.The sensitivity,specificity and accuracy were compared between DCE-MRI and DWI in the diagnosis of prostate cancer.Results Among the 50 cases with prostate cancer,there were 32 cases with prostate cancer and 18 cases with central cancer.Tmax,MSI and SER of prostate cancer were (69068.34 ± 18005) ms,(216.02 ± 43.24),(122.05 ± 17.34) respectively while of benign prostate hyperplasia were (83012.56 ± 24352.19) ms,(187.26 ± 29.35) and (108.37 ± 11.98) respectively.Tmax of prostate cancer was shorter than that of benign prostate hyperplasia while MSI and SER were than those of benign prostate hyperplasia (P＜0.05).The sensitivity,specificity and accuracy of DCE-MRI in the diagnosis of prostate cancer were 62.00％,90.00％ and 82.00％ respectively while of T2W1 were 71.00％,84.00％ and 76.00％ respectively (P＞0.05).Conclusion Both of DCE-MRI and DWI can be used for diagnosis of prostate cancer,with specific manifestations.