64层螺旋CT心脏一站式检查联合BNP、hs-cTnT在急性冠脉综合征的应用价值

目的应用64层螺旋CT心脏一站式检查联合脑钠肽(BNP)、高敏肌钙蛋白T(hs-cTnT)对急性冠状动脉综合征(ACS)患者心功能的评估价值。方法 59例急性冠脉综合征(ACS)及11例健康志愿者均进行CT心脏一站式检查,分别对冠状动脉及左心室射血分数(LVEF)进行CT数据分析,并测定血浆BNP值、hs-cTnT值,比较冠状动脉病变与心功能分级的关系,心功能分级与BNP、hs-cTnT、LVEF的差异及相关性分析。结果冠状动脉病变支数、狭窄程度与LVEF呈反比关系。左前降支、左回旋支、右冠状动脉对于左心室LVEF的影响程度依次递减。各级心功能患者血浆BNP浓度、hs-cTnT浓度明显高于健康志愿者,差异均有统计学意义(P0.01)。不同心功能级别患者、BNP、hs-cTnT与LVEF均呈明显负相关(r=-0.953、-0.832、-0.943,P0.01)。结论 ACS患者在进行心脏CT一站式检查,除了明确冠状动脉有否狭窄外,还能通过对原始数据的后处理对其左心室功能(LVEF)进行分析,并且同时结合血浆BNP、hs-cTnT检测,为临床诊治提供客观指标。

The Value of One-stop Cardiac Inspection by 64-slice CT Combined with BNP and hs-cTnT in Patients with Acute Coronary Syndromes

Objective To study the value of the One-stop cardiac inspection by 64-slice CT combined with BNP and hs-cTnT in acute coronary syndromes patient assessment. Methods 59 patients with ACS and 11 healthy volunteers were selected in this study, who underwent 64-slice CT One-stop cardiac inspection, and the CT data of coronary stenosis and left ventricular ejection fraction (LVEF), the level of BNP and hs-cTnT, the coronary stenosis, the value of LVEF, the level of BNP and hs-cTnT, and variable heart function were compared and analyzed.Results Count of coronary artery lesion is inversely proportional with degree of stenosis and LVEF. Left anterior descending and left circumflex branch and right coronary artery for diminishing the influence degree of the left ventricle LVEF into an inverse. Moreover, Cardiac function I, II, III and IV patients' concentration of BNP and hs-cTnT level were obviously higher than volunteers. Differences were statistically significant(P<0.01). Different level of cardiac function in patients with hs-cTnT, BNP was a negative correlation with LVEF (r=-0.953, -0.832, -0.943, P<0.01).Conclusion 64-slice CT One-stop cardiac inspection processed in patients with ACS, we could not only judge the stenosis of coronary artery, but also analysis the left ventricular function. LVEF combined with the plasma BNP & hs-cTnT detection can provide the quantitative analysis of heart function damage causing by the ACS. So as to provide objective index to clinical diagnosis and treatment.