超声造影与CTA评估阿托伐他汀对颈动脉斑块新生血管的治疗效果

目的使用超声造影及CTA评估阿托伐他汀对于颈动脉软斑块新生血管的治疗效果。方法所有患者规律服用20mg/d阿托伐他汀治疗,利用血脂检查、常规超声、超声造影及CTA进行治疗前后相关指标的评估。结果共入选34例患者,治疗后斑块积分、增强强度(EI)、曲线下面积(AUC)及增强后斑块的CT值与治疗前差异均有统计学意义(P0.05),并且治疗后6个月的斑块积分、增强强度(EI)、曲线下面积(AUC)及增强后斑块的CT值与治疗后3个月差异也均有统计学意义(P0.05)。各组均未出现终点事件及严重不良反应。结论超声造影及CTA可以用于评价颈动脉粥样斑块的临床风险及他汀类药物的治疗效果。

The Effect of Atorvastatin on Carotid Plaque Neovascularization by Contrast-Enhanced Ultrasound and CTA

Objective To evaluate the efficacy of atorvastatin in the treatment of carotid plaque neovascularization by contrast-enhanced ultrasonography(CEUS) and CTA. Methods All patients were treated with atorvastatin (20 mg/d) regularly. Blood lipid, routine ultrasound, CEUS and CTA were used to evaluate the relative indexes before and after treatment. Results 34 patients were enrolled. The plaques score, the intensity of enhancement (EI), the area under the curve (AUC) and CT value significantly decreased after treatment (P<0.05). And there were significant differences in plaque score, intensity of enhancement (EI), area under the curve (AUC), and plaque CT value at 6 months after the treatment, than those at 3 months after treatment. No end-point events or serious adverse events were observed in each group. Conclusion Ultrasonography and CTA can be used to evaluate the clinical risk of carotid atherosclerotic plaques and the therapeutic effect of statins.