| 瘦素基因及其受体基因多态性与抗精神病药源性肥胖的关联分析 |
| |
| 引用本文： | 姚培芬,张玉麟,梅轶,项志清,钱伊萍,陈荣富,汪栋祥,江三多.瘦素基因及其受体基因多态性与抗精神病药源性肥胖的关联分析[J].上海精神医学,2008,20(4):226-228. |
| |
| 作者姓名： | 姚培芬 张玉麟 梅轶 项志清 钱伊萍 陈荣富 汪栋祥 江三多 |
| |
| 作者单位： | 上海交通大学医学院附属精神卫生中心,200030 |
| |
| 基金项目： | 美国Stanley研究基金(021-012) |
| |
| 摘 要： | 目的探索瘦素基因和瘦素受体基因多态性与抗精神病药源性肥胖的关联性。方法采用PCR-RFLP法检测抗精神病药源性肥胖精神分裂症患者（86例）和健康对照者（96名）的瘦素基因G2548A和瘦素受体基因Gln223Arg位点单核苷酸多态性,比较两组间基因型和等位基因的频率。结果患者组瘦素基因的基因型AA、AG和GG分别为0.4884、0.3837和0.1279;对照组分别为0.5053、0.3579和0.1368。患者组瘦素受体基因的基因型AA、AG和GG分别为0.0233、0.2558和0.7209;对照组分别为0.0211、0.1895、和0.789。瘦素基因和瘦素受体基因的基因型频率和等位基因频率在2组间差异无统计学意义。结论瘦素基因及其受体基因多态性与抗精神病药源性肥胖无关联性。
|
| 关 键 词： | 瘦素 瘦素受体 基因 多态性 关联 抗精神病药 肥胖 |
Association study of leptin gene and leptin receptor gene with antipsychotic agent-induced weight gain |
| |
| Yao Peifeng,Zhang Yulin,Mei Yi,Xiang Zhiqing,Qian Yiping,Chen Rongfu,Wang Dongxiang,Jiang Sanduo.Association study of leptin gene and leptin receptor gene with antipsychotic agent-induced weight gain[J].Shanghai Archives of Psychiatry,2008,20(4):226-228. |
| |
| Authors: | Yao Peifeng Zhang Yulin Mei Yi Xiang Zhiqing Qian Yiping Chen Rongfu Wang Dongxiang Jiang Sanduo |
| |
| Institution: | Yao Peifeng, Zhang Yulin, Mei Yi, Xiang Zhiqing, Qian Yiping, Chert Rongfu, Wang Dongxiang, Jiang Sanduo( Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai 200030) |
| |
| Abstract: | Objective:To investigate the association of leptin gene and leptin receptor gene polymorphism with antipsychotic agent-induced weight gain. Methods: The frequencies of genotype and allele single nucleotide polymorphism of leptin gene(G2548A) and leptin receptor gene(Gln 223Arg)in antipsychotic agent-induced weight gain with schizophrenia (n=86) and health controls (n=96) in Shanghai population were detected and compared with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Result... |
| |
| Keywords: | Leptin Leptin receptor Gene Polymorphism Association Antipsychotics Obesity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
