| 多巴胺对外源性羟自由基致兔心肌损伤的作用 |
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| 引用本文： | 王莉 周冠怀. 多巴胺对外源性羟自由基致兔心肌损伤的作用[J]. 上海交通大学学报(医学版), 1999, 19(4): 315-318 |
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| 作者姓名： | 王莉 周冠怀 |
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| 作者单位： | 上海第二医科大学市六临床医学院麻醉科!200233(王莉)，上海第二医科大学药理教研室!200025(周冠杯，邱瑜，金正均) |
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| 摘 要： | 目的明确儿茶酚胺与缺血性损伤心肌间作用的病理生理影响。方法在外源性羟自由基所致家兔心肌损伤的模型上，观察心功能、心肌超微结构和血中脂质过氧化物（MDA）之间的关系以及多巴胺的影响。结果多巴胺加重心肌超微结构的损伤，并且有加重心肌脂质过氧化的倾向，与羟自由基对照组比较差异非常显著（P＜0．01）。结论多巴胺会延迟自由基损伤的心肌恢复，因而为评价多巴胺治疗心肌缺血／再灌注损伤后心功能低下状态的远期效果提供了研究资料。
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| 关 键 词： | 多巴胺 心肌损伤 羟自由基 丙二醛 |
Action of Dopamine on Hydroxyl Radical Induced Myocardial injury |
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| Wang Li, Zhou Guanhuai, Qiu Yu, et al. Action of Dopamine on Hydroxyl Radical Induced Myocardial injury[J]. Journal of Shanghai Jiaotong University:Medical Science, 1999, 19(4): 315-318 |
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| Authors: | Wang Li Zhou Guanhuai Qiu Yu et al |
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| Abstract: | Objective Definite the inter - pathophysiological influence of ischemic injury of myocardium. Methods An in vivo myocardial impairment model was created in rabbits with exogenous hydroxyl radical to investigate the effects of dopamine DA on hemodynamics, myocardial dynamics properties, lipid peroxide, and myocardial ultra structure. Res"lts Dopamine may exacerbate injured ultra - structure of myocardium and elicite an increment in myocardial lipid peroxidation. Dopamine and other positive inotropic drugs have clinically some beneficial effect on myocardial dysfunction following ischemia/reperfusion (I/R). COnclusion Dopamine may delay the recovery of injured myocardium from I/R by increasing myocardial oxygen demand and its infusion temporarily improved rabbit myocardial function. In vivo it was oxidized to oxygen free radical and could aggravate injured ultrastructure of myocardium as well. |
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| Keywords: | dopamine myocardial injury hydroxyl radical malondialdehyde |
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