| Dubin-Johnson综合征的病理学特征 |
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| 引用本文： | 向理科,罗子国,李圆圆. Dubin-Johnson综合征的病理学特征[J]. 中华肝脏病杂志, 2000, 8(1): 45-47 |
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| 作者姓名： | 向理科 罗子国 李圆圆 |
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| 作者单位： | 向理科（重庆医科大学病理学教研室 400016） 罗子国（重庆医科大学病理学教研室 400016） 李圆圆（重庆医科大学病理学教研室 400016） 张远国（重庆医科大学病理学教研室 400016） |
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| 摘 要： | 目的 探讨Ｄｕｂｉｎ－Ｊｏｈｎｓｏｎ综合征（Ｄｕｂｉｎ－Ｊｏｈｎｓｏｎ ｓｙｎｄｒｏｍｅ,ＤＪＳ）病人肝细胞内色素颗粒的本质。方法 应用光镜,组织化学,免疫组织化学和电镜技术对肝细胞内色素颗粒进行及其对Ｓ－１００蛋白和ＨＭＢ４５的表达。结果 组织学检查显示肝小叶结构正常,肝细胞内有大量棕褐色颗粒沉着,尤以小叶中央区明显。组织化学染色和超微结构观察结果证实色素颗粒具有脂褐素和黑色素的特征,免疫组织化
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| 关 键 词： | 免疫组织化学 病理学 超微结构 DJS综合征 |
| 修稿时间： | 1999-05-09 |
Clinical pathology of Dubin-Johnson syndrome |
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| XIANG Like, LUO Ziguo, LI Yuanyuan,et al.. Clinical pathology of Dubin-Johnson syndrome[J]. Chinese journal of hepatology, 2000, 8(1): 45-47 |
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| Authors: | XIANG Like LUO Ziguo LI Yuanyuan et al. |
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| Affiliation: | Department of pathology, Chongqing University of Medical Sciences, Chongqing 400016, China. |
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| Abstract: | Objective To investigate the property of pigment granules in the hepatocytes in patients with DubinJohnson syndrome. Method Light microscopy, histochemical, immnohistochemical and electron microscopy techniques were used to study the pigment glanules and the expression of S-100 protein and HMB45 in hepatocytes. Results Histological examination revealed normal lobular architecture and the abundont brown pigments which were chief'ly seen in the centrilobular zone hepatocytes. The pigment granules were evidenced to have the characterization of both lipofuscin and melanin by histochemical staining and ultrastructural studies and to have the featurts of the melanin by immnohistochemical staining. Conclusions The results suggest that the pigment grannies are lipfuscin-melanin complex in the hepatocytes in patients with Dubin-Johnson syndrome. |
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| Keywords: | Jaundice chronic iniopathic Histochemistry Immnohistochendsny Pathology clinical Ultrastructure |
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