A natural anti-T-cell receptor monoclonal antibody protects against experimental autoimmune encephalomyelitis |
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Authors: | Fernández-Malavé Edgar Stark-Aroeira Luiz |
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Institution: | Inmunología, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain. edfernan@med.ucm.es |
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Abstract: | The therapeutic potential of natural anti-T-cell receptor (TCR) antibodies is largely unknown. We investigated whether passive administration of C1-19, a novel natural anti-TCRVβ8 monoclonal antibody, could interfere with the development of EAE. Treatment with C1-19 prevented myelin basic protein (MBP)-induced EAE in Vβ8-sufficient B10.PL but not in Vβ8-deficient SJL mice. Furthermore, C1-19 reduced disease severity when administrated shortly after disease onset. These protective effects of C1-19 correlated with a Th2 bias of the cytokine response, in the absence of T-cell deletion or anergy. Together, these findings indicate that natural anti-TCR antibodies could function as therapeutic tools in autoimmune inflammatory diseases. |
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