Pharmacokinetics of tocainide in patients with severe renal failure |
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Authors: | J. Braun F. Sörgel F. Engelmaier W. P. Gluth U. Geßler |
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Affiliation: | (1) Institute of Nephrology, University of Erlangen-Nürnberg, Nürnberg, Federal Republic of Germany;(2) Division of Clinical Pharmacology, Carl Korth Institute for Cardiovascular Research, Erlangen, Federal Republic of Germany |
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Abstract: | Summary The plasma levels of tocainide have been followed after oral administration of 600 mg p.o. to 20 patients with renal failure due to various causes, and to 8 healthy controls. The peak plasma concentrations in the patients with pyelonephritis (3.80 µg/ml) and interstitial nephritis (3.74 µg/ml) but not in those with glomerulonephritis (3.17 µg/ml) differed from that in healthy volunteers (3.24 µg/ml). The renal clearance of tocainide was well correlated with the endogenous creatinine clearance and was dependent on urine pH. No difference in renal clearance was observed between the patients groups. It is suggested that the changes in plasma levels are a consequence of decreased renal clearance. Creatinine clearance was shown to be a poor estimator of tocainide clearance, which suggests that extrarenal clearance plays an important role in the handling of the drug in the body. The findings are used to suggest a safe dosage regimen. |
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Keywords: | tocainide renal failure pharmacokinetics oral dosing pharmacodynamics |
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