| 微量元素镉 硒对NIH小鼠超氧化物歧化酶的影响 |
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| 引用本文： | 魏经建,刘彩玉. 微量元素镉 硒对NIH小鼠超氧化物歧化酶的影响[J]. 微量元素与健康研究, 2003, 20(3): 3-5 |
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| 作者姓名： | 魏经建 刘彩玉 |
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| 作者单位： | 河南省肿瘤研究所,郑州,450003 |
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| 摘 要： | 目的 :了解镉、硒对NIH小鼠超氧化物歧化酶 (SOD)活性变化的作用。方法 :采用Oyanagui和贺锐的方法测定Cu—ZnSOD和Mn—SOD活性。结果和结论 :镉能使NIH小鼠内脏组织细胞的Cu—ZnSOD活性降低 ,Mn—SOD活性相应增高 ,硒能拮抗这种作用 ,从酶角度阐明了镉的致癌机理
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| 关 键 词： | 微量元素 超氧化物歧化酶 小鼠 |
| 文章编号： | 1005-5320(2003)03-0003-03 |
| 修稿时间： | 2003-03-05 |
The influence of Trace element Cadmium and Selenium Upon Superoxide dismutase in NIH mouse |
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| WEI Jing-jian,LIU Cai-yu. The influence of Trace element Cadmium and Selenium Upon Superoxide dismutase in NIH mouse[J]. Studies of Trace Elements and Health, 2003, 20(3): 3-5 |
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| Authors: | WEI Jing-jian LIU Cai-yu |
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| Abstract: | objective: A explore the variation for Trace element cadmium and selenium upon Superoxide dismutase activity (SOD)in NIH mouse. Methods: We determined the activity of Cu-Zn SOD and Mn-SOD With Oyanagui and Herui's methods. Results and Conclusion: The result suggested that the Cadmium have been made the Cu-Zn SOD activity level of tissue cell in internal organs decrease?and had a activity of Mn-SOD Were more higher. Selenium have a antagonize. We have elucidated the mechanism of carcinogenesis of cadmium at a enzymologic angle. |
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| Keywords: | Trace element Superoxide dismutase mouse |
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