盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效研究

目的：研究盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效。方法研究纳入98例确诊的慢性支气管炎患者，其中男性75例，女性23例。将患者随机分为单纯盐酸氨溴索治疗的对照组（49例）和联合了N-乙酰半胱氨酸治疗的观察组（49例）。此外，两组均给予抗炎等常规治疗。按上述方案治疗6个月后，比较两组的治疗效果，用力肺活量（FVC）、FEV1/预计值（%）、FEV1/FVC（%）等肺功能指标以及生活质量评分在治疗前后的改变。结果两组均能在消除咳嗽、咳痰、喘息等症状方面取得良好疗效，在影像学检查指标方面也均达到预期的治疗效果。但联合N-乙酰半胱氨酸治疗的观察组总体有效率更高，与对照组相比差异具有统计学意义（P〈0.05），此外观察组患者的肺功能指标在治疗后优于对照组（P〈0.05），生活质量评分也高于对照组（P〈0.05）。结论盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效较优，可以在临床中推广。

Effect observation of ambroxol hydrochloride combined with N-acetylcysteine in the treating of chronic bronchitis

Objective To investigate the effect of ambroxol hydrochloride combined with N-acetylcysteine in the treating of chronic bronchitis. Methods 98 cases （male n=75, female n=24） with chronic brochitis were divided into the control group （n=49） and the observation group （n=49） randomly. All groups received basic treatment such as anti-inflammatory therapy. Moreover, in the control group patients were also treated with f ambroxol hydrochloride and in the observation group fambroxol hydrochloride were used with N-acetylcysteine. Results All group had a good effect on relieving cough, sputum and other symptoms. Nevertheless in the observation group, the total effective rate was higher than that in the control group （P〈0.05）. Compared with control group, observation group showed greater improvement in pulmonary function and life quality. Conclusion The effect of ambroxol hydrochloride combined with N-acetylcysteine in the treating of chronic bronchitis is better and satisfying and worthy of being used.