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Prefabricating bone in muscle by using free tibial periosteal grafts and self-reinforced polyglycolide and poly-L-lactide pins |
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| Authors: | K A Puumanen T O Böhling H K Pihlajamäki P O Törmälä T H Waris N A Ashammakhi |
| Institution: | Myrttitie 11, 00720 Helsinki, Finland, Department of Pathology, Hartman Institute, University of Helsinki, Helsinki, Finland, Department of Surgery, Military Central Hospital, Helsinki, Finland, Institute of Biomaterials, Tampere University of Technology, Tampere, Finland, Division of Plastic Surgery, Department of Surgery, Oulu University Hospital, Oulu, Finland, |
| Abstract: | To investigate the possibility of prefabricating bone of predetermined form in muscle using free tibial periosteal grafts and biodegradable pins, operations were performed on 12 growing rabbits. In each animal, (1) a graft around a self-reinforced polyglycolide (SR-PGA) pin, (2) a graft around a self-reinforced poly-L-lactide (SR-PLLA) pin, (3) a SR-PGA pin, and (4) a SR-PLLA pin were implanted in the dorsal muscles for 6 weeks. Histological and histomorphometric evaluations were performed. Bone formation from periosteal grafts was observed in all 12 animals. The shape of the newly-formed bone was grossly cylindrical in all specimens except one. Bone formation was stronger around the SR-PGA pins than around the SR-PLLA pins. The pins without grafts did not induce any bone formation, but fibrous tissue encapsulation instead. A mild foreign body reaction was elicited by SR-PGA pins, while it was almost absent with SR-PLLA pins. It is thus possible to prefabricate bone in a cylindrical form in growing rabbits using free tibial periosteal grafts and SR-PGA or SR-PLLA pins implanted in muscle. |
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