大肠癌组织环氧化酶-2基因表达在哈萨克族与汉族患者中的差异性

目的]探讨环氧化酶-2（COX-2）在哈萨克族人群大肠癌患者中的表达．以及与汉族人群是否存在差异。方法]采用免疫组化Elivision^TM plus法检测26例哈萨克族和28例汉族大肠癌患者的正常组织及肿瘤组织中的COX-2蛋白的表达。结果]19．2％（5／26）哈萨克族大肠癌患者正常组织中COX-2蛋白表达阳性，而92．3％（24／26）肿瘤组织中COX-2蛋白的表达阳性．差异有显著性（P〈0．01），COX-2在哈萨克族患者各分期肿瘤组织中的表达无差异（P〉0．05）。COX-2在两组患者正常组织中的表达情况无差异，肿瘤组织中也如此。结论]COX-2在哈萨克族大肠癌的发病中起着重要作用，在哈萨克族大肠癌患者中的表达与汉族患者无差异性。

Difference of Cyclooxygenase-2 Expression in Colorectal Cancer Between Kazakh Nationality and Han Nationality

Purpose] To investigate the cyclooxygenase-2 （COX-2） expression in colorectal cancer in population of Kazakh nationality and its difference with that in Han nationality. Methods ] The expression of COX-2 in the normal and cancer tissues in 26 cases of Kazakh and 28 cases of Han nationality were detected by immunohistochemical ElivisionTM plus method. Results] In Kazakh the positive expression of COX-2 was 19.2% （5/26） in normal tissues and 92.3% （24/26） in cancer tissues, with significant difference （P〈0.01）, but no difference was found in different stages （P〉0.05）. There is no difference of the expression of COX-2 in normal or tumor tissues between Kazakh and Han nationality. Conclusions] COX-2 plays an important role in the carcinogenesis with colorectal cancer. There is no difference of the COX-2 expression between the Kazakh and the Han nationality with colorectal cancer.