脑梗塞患者血清肺炎衣原体特异性抗体的检测

目的探讨肺炎衣原体(CPn)感染与动脉血栓性脑梗塞的关系.方法用酶联免疫吸附试验(ELISA)法测定了112例脑梗塞患者和50例其他疾病患者的血清肺炎衣原体特异性IgG抗体及IgM抗体.结果肺炎衣原体慢性感染率分别为脑梗塞组的85.71%(96/112)和对照组48.00%(24/50),脑梗塞患者肺炎衣原体慢性感染率均明显高于对照组,肺炎衣原体IgG阳性病例血清TG浓度明显高于肺炎衣原体IgG阴性的病例(P＜0.05);HDL-C则明显低于阴性组.结论脑梗塞患者肺炎衣原体感染率明显增高,提示肺炎衣原体感染可能与脑梗塞有关.其可能的机制是肺炎衣原体感染后形成免疫复合物沉积在血管壁,引起血管局部损伤;并改变了血脂浓度,增加了脑血管病发生的危险性.

Detection of Chlamydia Pneumoniae - specific Anti - bodies in Sera of Patients with Cerebral Infarction

Objective To study the asssociation between prior infection with chlamydia pneumnoniae (CPn) and Cerebral infaxction. Methods Chlmgdia pneumoniae-specific IgG and IgM antibodies were measured in 112 patients with cerebral infarction and 50 controls with other diseases by enzyme linked immunosorbent assay test and serum concentrations of total cholesterol (TC), triglyceride (TG). Results The positive rate of specific IgG antibodies was 85.71% (96/112) in patients with the cerebral infarction group and 48%(24/50) in the control group. The positive rate of specific IgG antibodies in patients with cerebral infarction group were significantly higher than those in controls. Conclusion There may exist an association between chronie chlamydia pneumoniae infection and Cerebral infarction. Possible mechanism was that CP infection might modify the serum lipid concentrations in a way that could increase the risk of Cerebral infarction.