中国老年人消化性溃疡危险因素的累积Meta分析

目的 分析中国老年人消化性溃疡发病相关危险因素,为采取相应的预防控制措施提供参考依据。方法 检索中国万方数据库和中国知网数据库(CNKI),收集自建库至2017年6月公开发表关于老年人消化性溃疡危险因素的研究文献;应用Stata14.0对纳入的文献进行统计分析。结果 最终纳入15篇中文文献,累计病例组3920例,对照组8146例,老年人消化性溃疡的危险因包括:吸烟、饮酒、Hp感染、服用非甾体类药物、抑郁症状。普通Meta分析危险因素的合并OR值及95%CI分别为2.68(2.10,3.27)、2.35(1.62,3.07)、2.60(1.79,3.40)、5.52(3.30,7.74)、2.92(2.39,3.46);累积Meta分析显示,按照发表年先后顺序累积分析后,吸烟、饮酒、Hp感染、服用非甾体类药物、抑郁症状的OR值及其95%CI均逐渐稳定并且有较好的变化趋势;可确定危险因素最初被证实具有统计学意义的时间。结论 在时间趋势方面,吸烟、饮酒、服用非甾体类药物没有检出明显的时间趋势,Hp感染、抑郁症状存在时间趋势。吸烟、饮酒、Hp感染、服用非甾体类药物、抑郁症状均为老年人消化性溃疡的危险因素且逐渐稳定并且有较好的变化趋势。

Risk factors for peptic ulcer in the elderly:a cumulative meta-analysis

Objective To analyze the risk factors related to peptic ulcer in the elderly in China,so as to provide reference for taking appropriate preventive and control measures.Methods Studies published till 2017 on risk factors for peptic ulcer in the Chinese elderly retrieved through China National Knowledge Infrastructure (CNKI) and Wan-fang Database were analyzed by Stata 14.0 software.Results A total of 15 studies were included and 3920 cases were in the case group and 8146 cases were in the control group.Smoking,drinking,Hp infection,taking NSAID and depressive symptoms were the risk factors of the elderly people who suffered peptic ulcer.The combined OR values and 95%CI values from meta-analysis were 2.68(2.10,3.27),2.35(1.62,3.07),2.60(1.79,3.40),5.52(3.30,7.74) and 2.92(2.39,3.46),respectively.After accumulating analysis according to the order of publication,the OR values and 95%CI values were gradually stable and had a good trend in cumulative meta-analysis.The time when these factors appeared first could be confirmed.Conclusion In terms of time trend,there are no significant trends in smoking,drinking,and taking NSAID and there is a tendency for Hp infection and depressive symptoms.Smoking,drinking,Hp infection,taking NSAID and depressive symptoms are the risk factors of peptic ulcer among the elderly,and their OR values are gradually stable and 95%CI values turn narrow by accumulation in chronological order.