改良重症超声快速管理方案对非计划入ICU患者的评估价值

  目的  探讨改良重症超声快速管理(modified critical care ultrasonic examination，M-CCUE)方案对非计划入ICU患者的评估价值，并分析其是否会影响医疗行为及预后判断。  方法  回顾性收集并分析2015年12月至2016年6月北京协和医院重症医学科非计划收治患者的相关临床资料，包括血流动力学指标、器官及组织灌注指标和预后评价指标。所有入选患者在入室30 min内完成初始M-CCUE评估，根据M-CCUE评分系统予以评分(M-CCUE score，MCS)。分析MCS与预后的相关性及对治疗策略的影响。  结果  共计272例符合入选和排除标准的非计划入ICU患者纳入本研究，其中仅3例(1.1%，3/272)患者在M-CCUE评估方案中未发现异常，139例(51.1%，139/272)因评估结果改变了药物治疗方案，81例(29.8%，81/272)进行了有创检查或治疗。MCS与患者28 d死亡率(r=0.432，P=0.020)、48 h死亡率(r=0.594，P=0.008)、机械通气时间(r=0.454，P=0.040)、ICU住院时间(r=0.563，P=0.003)均呈正相关。多因素回归分析显示，年龄、急性生理与慢性健康状况评分Ⅱ(acute physiology and chronic health evaluation Ⅱ，APACHE Ⅱ)、MCS和序贯性器官衰竭评分(sequential organ failure assessment，SOFA)是28 d死亡的独立危险因素，同时年龄、MCS和SOFA是48 h死亡的独立危险因素。  结论  M-CCUE能够实现早期床旁心肺功能评估，其量化评估结果可改进临床治疗方案，预测患者预后。

Evaluating Value of Modified Critical Care Ultrasonic Examination Protocol for the Patients Unplanned Admission to the ICU

  Objective  The purpose of this study was to investigate the evaluating value of the modified critical care ultrasonic examination (M-CCUE) protocol for those patients unplanned admission to the ICU and to analyze whether it could influence the management decision and predict the outcome.  Methods  The clinical data of patients unplanned admission to the department of critical care medicine of Peking Union Medical College Hospital from December 2015 to June 2016 were collected and analyzed retrospectively, including the hemodynamic index, organ and tissue perfusion index, and prognosis evaluating index. All the enrolled patients received the M-CCUE within 30 minutes after admission to our department and were scored according to the M-CCUE scoring system (MCS). The correlation between MCS and the prognosis and its effect on the management decision were analyzed.  Results  A total of 272 patients who met the inclusion and exclusion criteria were enrolled in this study. Only 3 patients (1.1%, 3/272)did not show any anomaly in M-CCUE; the management decision of 138 patients (50.7%, 138/272), was adjusted; 81 patients (29.8%, 81/272) underwent additional invasive diagnostic procedures or treatment. The univariate analysis revealed that MCS correlated positively with the 28-day mortality (r=0.432, P=0.020), 48-hour mortality (r=0.594, P=0.008), ventilator time (r=0.454, P=0.040), and length of ICU stay (r=0.563, P=0.003). The multivariate analysis demonstrated that age, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), MCS, and sequential organ failure assessment score were the independent risk factors for the 28-day mortality, while age, MCS, and sequential organ failure assessment score were the independent risk factors for the 48-hour mortality.  Conclusions  M-CCUE protocol can achieve the early bedside cardiopulmonary function assessment; its quantitative assessment results are associated with the prognosis and might improve the clinical management decision.