Quality of life after growth hormone therapy and induced puberty in women with Turner syndrome |
| |
Authors: | Bannink Ellen M N Raat Hein Mulder Paul G H de Muinck Keizer-Schrama Sabine M P F |
| |
Institution: | Department of Pediatrics, Division of Endocrinology, Erasmus MC-Sophia Children's Hospital, University Medical Centre, Rotterdam, The Netherlands. e.bannink@tiscali.nl |
| |
Abstract: | OBJECTIVE: To evaluate health-related quality of life (HRQoL) in young women with Turner syndrome (TS) after long-term growth hormone (GH) therapy and induced puberty and to analyze whether HRQoL was influenced by auxologic parameters, pubertal development, or subjective parameters. STUDY DESIGN: The study group comprised 49 women with TS, mean (standard deviation) age 19.6 (+/-3.0) years, all former participants of 2 GH studies, > or =6 months after GH discontinuation. Puberty was induced by estrogen treatment, at mean age 12.9 (+/-1.1) years. HRQoL was measured by self-reports of the 2 generic questionnaires, SF36 and TAAQOL. As an additional source of information on HRQoL, we applied parental proxy reports. RESULTS: HRQoL of the women with TS was normal. Remarkably, the women with TS had higher HRQoL scores on some of the scales, including "social functioning" and "role-emotional." Satisfaction with height and breast development had a positive influence on several HRQoL scales. CONCLUSIONS: The young women with TS who reached normal height and had age-appropriate pubertal development reported normal HRQoL. The relatively high scores on some of the HRQoL scales can be explained by an estrogen effect or by a possible response shift, indicating a different internal reference in women with TS. We hypothesize that GH and estrogen treatment positively influenced HRQoL in young women with TS. |
| |
Keywords: | DRS Dose-response study FRS Frequency-response study GH Growth hormone HRQoL Health-related quality of life QoL Quality of life SES Socioeconomic status SDS Standard deviation score SF36 Short Form-36 Health Survey TAAQOL TNO/AZL Adult Quality of Life Survey TS Turner syndrome |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|