L-肉碱对奥硝唑致大鼠精子及生育力损伤的保护作用观察

目的探讨L-肉碱(LC)对奥硝唑(ORN)所致大鼠精子及生殖功能损伤的保护作用。方法 40只健康成年雄性SD大鼠随机均分为5组,各8只。A组:予以0.5%羧甲基纤维素钠(溶剂)灌胃、1 ml/d;B组:ORN 400mg/(kg·d)灌胃;C组:ORN 800 mg/(kg·d)灌胃;D组:ORN 400 mg/(kg·d)+LC 100 mg/(kg·d)灌胃;E组:ORN 800 mg/(kg·d))+LC 100 mg/(kg·d)灌胃。均连续灌胃20 d,末次给药24 h后,各组均麻醉后处死大鼠4只,取附睾尾部行精子计数,检测精子活动率及存活率;余大鼠与雌鼠合笼行交配试验。结果与A组相比,B、C组大鼠附睾尾部精子计数、活动率和存活率明显下降(P均<0.05),B组平均胚胎数显著降低(P<0.05),C组无交配雌鼠受孕(P<0.01)。与B组相比,D组大鼠附睾尾部计数、精子活动率和存活率明显增加(P均<0.05),平均胚胎数显著增加(P<0.05),与A组近似(P均>0.05)。E组与C组近似(P均>0.05),与A组各项指标比较,P均<0.01。结论 LC对ORN引起的雄性大鼠精子及生育力损伤具有一定...

Protective effect of L-carnitine in the injury induced by ornidazole on the spermatozoon and fertility of male rats

Objective To investigate the protective effect of L-carnitine in the injuryinduced by ornidazole on the spermatozoon and fertility of male rats.Methods 40 male SD rats(200～230 g) were randomly divided into S groups;group A:0.5%sodium carboxymethyl cellulose given by oral gavage;group B:ORN[400 mg/(kg·d)]given by oral gavage ;group C:ORN[800 mg /(kg·d)]given by oral gavage;group D:ORN[400 mg/(kg·d)]plus LC[100 mg/(kg·d)]given by oral gavage;group E:ORN[800 mg/(kg·d)]plus LC[100 mg/(kg·d)]given by oral gavage...