Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy |
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| Authors: | Contin M Mohamed S Albani F Riva R Baruzzi A |
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| Affiliation: | UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche, [corrected] Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy. manuela.contin@unibo.it |
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| Abstract: | We aimed to compare apparent steady-state oral clearance (CL/F) of the antiepileptic drug levetiracetam (LEV) in elderly (66-80 years, n=105) and very elderly (81-96 years, n=70) vs nonelderly (30-65 years, n=97) patients with epilepsy. Median weight-normalized CL/F (mLmin(-1)kg(-1)) decreased from 1.23 (nonelderly) to 0.83 (elderly) and 0.59 (very elderly) (p<0.001). LEV CL/F significantly declines with aging, elderly and very elderly patients requiring an about 30% and 50% lower dose, respectively, compared to nonelderly adults to achieve a given LEV plasma concentration. |
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