Diffuse large B-cell lymphoma presenting as a chronic leg ulcer: the importance of repeat tissue biopsy |
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Authors: | Khan Junaid Alam Usman Farooq Abbasi Shaista Shoab Syed Sulaiman |
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Affiliation: | Academic Vascular Surgical Unit, Hull Royal Infirmary, UK. junaid.khan@hey.nhs.uk |
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Abstract: | Ulceration of the leg is often associated with significant consequences for both the individual and society. The diagnosis of chronic leg ulcer is not appropriate. Primary cutaneous diffuse large B-cell lymphoma (PCLBCL), leg type, is a distinct clinicopathological entity. Chemotherapy in the form of R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, Oncovin and prednisolone) is considered to be the first line of treatment for these lymphomas. We report a 69-year-old man who presented with chronic leg ulcer with a first negative biopsy and a diagnosis of PCLBCL, leg type, verified on the subsequent biopsy. This case report emphasises the importance of differential diagnosis of lymphoma in non-healing ulcers and also the value of repeat tissue biopsy in cases with a negative initial result but strong clinical suspicion. |
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