Decreased activity of scavenger enzymes in human hepatocellular carcinoma,but not in liver metastases |
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Authors: | Massimo Casaril Flavia Corso Antonella Bassi Franco Capra Giovanni Battista Gabrielli Anna Maria Stanzial Nicola Nicoli Roberto Corrocher |
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Institution: | (1) Istituto di Biochimica Clinica, University of Verona, Via delle Menegone 10, I-37134 Verona, Italy;(2) Clinica Medica, University of Verona, Via delle Menegone 10, I-37134 Verona, Italy;(3) Patologia Chirurgica, University of Verona, Via delle Menegone 10, I-37134 Verona, Italy;(4) Istituto di Patologia Medica, Cattedra di Medicina Interna, Policlinico Borgo Roma, I-37134 Verona, Italy |
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Abstract: | Summary To investigate the role of oxygen free radicals in hepatocellular carcinoma we assayed tissue scavenger enzymes (superoxide
dismutase and selenium-dependent glutathione peroxidase) in liver homogenate, plasma concentrations of vitamins A and E and
the serum selenium level from 19 control patients, 23 cases of hepatocellular carcinoma and 18 cases of metastases to liver
from different carcinomas. In hepatocellular carcinoma tissue the enzyme activities were all significantly lower than in control
liver and in metastases-bearing liver; the enzyme activities of the latter tissues were not different from control liver.
In contrast, normal liver adjacent to the hepatocellular carcinoma had decreased activity of superoxide dismutase. Serum selenium
concentrations were significantly decreased in patients with hepatocellular carcinoma and those with liver metastases, while
vitamin A was significantly decreased only in the former. These findings suggest that hepatocellular carcinoma develops in
liver with severe impairment of cellular antioxidant systems, since, in patients with liver metastases from different cancers,
despite low selenium concentrations, cellular scavenger enzymes have normal activities. |
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Keywords: | Hepatocellular carcinoma Selenium Glutathione peroxidase Superoxide dismutase Metastases |
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