羟基磷灰石与聚乙烯复合材料的组织相容性和骨传导性实验研究

目的 探讨羟基磷灰石与聚乙烯复合材料(hydroxyapatite/high-density polyethylene composite,HA/PE)的组织相容性和可塑性.设计 实验性研究.研究对象 45只新西兰白兔.方法 实验动物随机分为HA/PE复合材料、多孔HA材料和多孔PE材料植入组,每组各15只.三组动物分别于眶下缘植入HA/PE复合材料、多孔HA及多孔PE材料三种不同植入物.于术后1、4、8、12、24周行大体、光学显微镜、扫描电镜检查.主要指标 植入物愈合及植入物内出现骨组织情况.结果 植入物无脱出、移位,与周围组织愈合紧密.HA/PE组术后1周即有成纤维细胞及新生血管长入,术后12周及24周可见成骨细胞、骨细胞等骨组织.HA组术后8周可见成骨细胞,24周孔隙内充满骨细胞.PE组可见成纤维细胞及新生血管长入,未见骨组织.结论 HA/PE既具有HA良好的生物相容性及骨传导性,又具有聚乙烯材料良好的可塑性,有望成为较理想的骨替代材料.

Experimental study of biocompatible and osteoinductive behavior of hydroxyapatite/polyethylene

Objective To explore the histocompatibility and plasticitity of hydroxyapatite/high-density polyethylene composite (HMPE). Design Experimental study. Participants Forty-five rabbits. Methods Rabbits were randomly devided into HA/PE, HA and PE surgical groups, every group included 15 rabbits. Osteoeetomy of orbital rim and implantation (HA/PE, HA and PE materials were used) were performed on 3 groups of the rabbits. At 1st week, 4th week, 8th week, 12th week and 24th week of postoperation, we took out the sa...