Is there a link between insulin resistance and inflammatory activation in preeclampsia? |
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| Authors: | Marco Scioscia Pantaleo Greco Luigi E. Selvaggi Thomas W Rademacher |
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| Affiliation: | 1. Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy;2. Department of Perinatal Medicine, Tor Vergata University, Rome, Italy;3. Department of Surgical Sciences, Division of Obstetrics and Gynaecology, University of Foggia, Italy;4. Department of Gynaecology Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy;5. Department of Immunology and Molecular Pathology, Molecualr Medicine Unit, Royal Free and University College London Medical School, London, United Kingdom |
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| Abstract: | Preeclampsia is a severe complication of human pregnancy and an insulin resistant state has been demonstrated in this multisystem disorder, although its bases remain unclear. Inositol phosphoglycans P-type belongs to a family of putative insulin mediators and was described to exert many insulin-like effects on lipid and glucose metabolism. A definite association between this molecule and preeclampsia was reported. The systemic inflammatory activation that occurs in preeclampsia as a consequence of the immunological dysfunction can exacerbate placental insulin resistance leading to an over-expression of P-IPG as a counterregulatory mechanism to insulin resistance. Besides, the lipidic form of P-IPG was reported to be similar to endotoxins, and may represent the link between insulin resistance, systemic inflammation and increased angiogenic factors. In this article we propose a new working theory on insulin resistance and preeclampsia. |
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