益肾健脾清利活血法治疗慢性肾小球肾炎早中期肾衰竭的临床观察

目的观察益肾健脾清利活血法治疗慢性肾小球肾炎早中期肾衰竭的临床疗效。方法选择符合入选标准的慢性肾小球肾炎早中期肾衰竭患者35例,随机分为2组。对照组15例予保肾片4片,每日3次口服;百令胶囊或金水宝4片,每日3次口服。治疗组20例在对照组基础上予益肾健脾、清利活血中药汤剂,每日1剂,水煎分2~3次口服。2组均予基础治疗,3个月为1个疗程,1个疗程后统计疗效。每2周测定尿蛋白1次,观察血肌酐(Cr)、临床症状积分的变化情况。结果治疗组总有效率75.0%,对照组总有效率66.7%,2组比较差异无统计学意义(P>0.05);治疗组治疗后症状积分减少,与治疗前比较差异有统计学意义(P<0.01),与对照组治疗后比较差异有统计学意义(P<0.01);治疗组尿蛋白有下降趋势,与治疗前比较差异有统计学意义(P<0.05);治疗组治疗后Cr降低,与治疗前比较差异有统计学意义(P<0.05),与对照组治疗后比较差异有统计学意义(P<0.05)。结论益肾健脾清利活血法治疗慢性肾小球肾炎早中期肾衰竭可稳定肾功能,延缓肾功能恶化的速度。

Clinical observation on the therapeutic effect of Yishenjianpiqinglihuoxue decoction on renal failure at early and middle stage caused by glomerular nephritis

Objective To observe the therapeutic effect of Yishenjianpiqinglihuoxue decoction on renal failure at early and middle stage caused by glomerular nephritis.Methods 35 patients were randomly divided into two groups.15 patients in control group were treated by Baoshen tablets 4 tablets once,3 times a day,with Bailing capsule or Jinshuibao tablets 4 pills once,3 times a day;20 patients in treatment group,on the basis of control group,were treated by Yishenjianpiqinglihuoxue decoction,one dose a day,decocted in water per os(2-3 times),with a treatment course of 3 months.The therapeutic effects were evaluated after one treatment course for both groups.Results The total effective rates in treatment group and control group were 75.0% and 66.7% respectively,there was no significant difference between two groups(P<0.05),but the scores of symptoms in treatment groups were significantly decreased after the treatment,as compared with those before the treatment(P<0.01),and so did with those in control group after treatment(P<0.01).There was a significant difference in the decrease of urinary protein in treatment group,as compared with that before treatment(P<0.05).After treatment Cr was obviously reduced in treatment group,as compared with that before treatment(P<0.05),and so did with that in control group after treatment(P<0.05).Conclusion Yishenjianpiqinglihuoxue decoction is effective in treating renal failure at early and middle stage caused by glomerular nephritis,which can improve kidney function and delay the deterioration of renal function.