Identification of biclonal (duplex) leukaemic cells expressing either CD4+/CD8- or CD4-/CD8+ from a patient with adult T-cell leukaemia/lymphoma |
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| Authors: | Seiji Kondo Tomio Kotani Shinichiro Tsumori Shinichiro Narahara Yatsuki Aratake Masako Kobayashi Masayoshi Takahashi Shouhei Inoue Sachiya Ohtaki |
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| Institution: | Blood Transfusion Division, Miyazaki;Department of Laboratory Medicine, Miyazaki;Central Laboratory for Clinical Investigation, Miyazaki;Department of Dermatology, Miyazaki Medical College, Kiyotake, Miyazaki;Genetic Laboratory, SRL Inc., Hachioji, Tokyo, Japan |
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| Abstract: | A 24-year-old Japanese woman was admitted to our hospital in 1987 with a chief complaint of skin eruptions, and was diagnosed as having chronic ATLL. In 1993 the leucocyte count increased gradually to 126.0x109/l with 91.5% abnormal lymphocytes expressing two different types of antigenicity, either CD4+/CD8- or CD4-/CD8+. Monoclonal integration of human T-cell lymphotropic virus type-I proviral DNA was detected at different sites of the genomic DNA in each cell type. These studies clearly indicate that CD4+/CD8- and CD4-/CD8- leukaemic cells originated from two independent clones. |
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| Keywords: | ATLL biclonal CD4 CD8 proviral DNA |
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