| 放射免疫法测定抑郁症患者血清脱氢表雄酮变化 |
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| 引用本文： | 张海三,张红星,孟焱,赵晶媛,杜云红. 放射免疫法测定抑郁症患者血清脱氢表雄酮变化[J]. 标记免疫分析与临床, 2009, 16(2): 84-87 |
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| 作者姓名： | 张海三 张红星 孟焱 赵晶媛 杜云红 |
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| 作者单位： | 新乡医学院第二附属医院,河南,新乡,453002 |
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| 摘 要： | 了解放射免疫法测定血清脱氢表雄酮（dehydroepiandrostemne，DHEA）的可靠性、抑郁症患者DHEA水平及抗抑郁治疗后的变化。选取抑郁症患者及正常对照志愿者各40名，8：00-9：00AM空腹时抽取肘静脉血，放射免疫分析法测定对照组和患者组治疗前后DHEA浓度。结果显示，患者组治疗前血清DHEA水平明显低于对照组（P=0．001），治疗后明显升高（P=0．000），且高于对照组（P=0．001）；男性组和女性组治疗前后血清DHEA浓度均有显著性差异（P值均为0．000）。结论：放射免疫法测定DHEA简便、可靠、易行，适合临床及研究应用；血清DHEA水平低下可能与抑郁有关，抗抑郁药物治疗后DHEA升高，这种变化与性别无关。
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| 关 键 词： | 放射免疫分析 抑郁症 神经甾体 脱氢表雄酮 |
Changes of Serum Dehydroepiandrosterone in Patients with Depression Measured by Radioimmunoassay |
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| ZHANG Hai-san,ZHANG Hong-xing,MENG Yan,ZHAO Jing-yuan,DU Yun-hong. Changes of Serum Dehydroepiandrosterone in Patients with Depression Measured by Radioimmunoassay[J]. Labeled Immunoassays and Clinical Medicine, 2009, 16(2): 84-87 |
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| Authors: | ZHANG Hai-san ZHANG Hong-xing MENG Yan ZHAO Jing-yuan DU Yun-hong |
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| Affiliation: | ZHANG Hai-san,ZHANG Hong-xing,MENG Yan,ZHAO Jing-yuan,DU Yunhong(The Second Affiliation Hospital of Xinxiang Medical University,Xinxiang 453002,China) |
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| Abstract: | To evaluate the reliability of radioimmunoassay for measuring serum neurosteroid dehydroepiandrosterone(DHEA)and to investigate the changes of serum DHEA level in depressive patients after treatment,the serum levels of DHEA in 40 health controls and in 40 depressive patients before and after treatment were measured by radioimmunassay.The results showed that the serum levels of DHEA in patient group before treatment were significantly lower than that in control group(P=0.001);it increased significantly after... |
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| Keywords: | Depression Neurosteroid Dehydroepiandrosterone |
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