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Lactate oxidation by skeletal muscle during sustained contraction in vivo |
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| Authors: | Anna Luisa Granata Menotti Midrio Andrea Corsi |
| Affiliation: | (1) National Research Council Unit for Muscle Biology and Physiopathology, Institute of General Pathology, and Institute of Human Physiology, University of Padua, I-35100 Padova, Italy;(2) Institute of Experimental Pathology, University of Ancona, I-60100 Ancona, Italy;(3) Present address: Facoltà di Medicina, Università di Ancona, I-60100 Ancona, Italy |
| Abstract: | Summary Estimation of lactate oxidation in vivo was carried out by a tracer technique in the muscles of the lower hindleg of the dog during tetani of different duration. The fractional (%) rate of lactate oxidation increased markedly, compared with that of the resting muscle, after the first 2 min of stimulation. Lactate oxidation afforded a large contribution to the total oxygen consumption. Fatigue appeared to play a role in limiting lactate oxidation in the later phase of sustained contraction. |
| Keywords: | Skeletal muscle metabolism Sustained contraction Lactate oxidation Oxygen consumption Fatigue |
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