首页 | 本学科首页   官方微博 | 高级检索  
     


Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas
Authors:Salaverria Itziar  Beà Silvia  Lopez-Guillermo Armando  Lespinet Virginia  Pinyol Magda  Burkhardt Birgit  Lamant Laurence  Zettl Andreas  Horsman Doug  Gascoyne Randy  Ott German  Siebert Reiner  Delsol Georges  Campo Elias
Affiliation:Haematopathology Section, Departments of Pathology;and Haematology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain;, Inserm U-563, 'Centre de Physiopathologie de Toulouse-Purpan' and Department of Pathology, Centre Hospitalier Universitaire de Purpan, Toulouse, France;, Department of Paediatric Haematology and Oncology, Justus-Liebig University, Giessen;, Institute of Pathology, University of Würzburg, Würzburg, Germany;, Department of Pathology, British Columbia Cancer Agency, Vancouver, Canada;, and Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel, Germany
Abstract:Anaplastic large cell lymphoma (ALCL) is a T/null-cell neoplasm characterized by chromosomal translocations involving the anaplastic lymphoma kinase (ALK) gene (ALK). Tumours with similar morphology and phenotype but negative for ALK have been also recognized. The secondary chromosomal imbalances of these lymphomas are not well known. We have examined 74 ALCL, 43 ALK-positive and 31 ALK-negative, cases by comparative genomic hybridization (CGH), and locus-specific alterations for TP53 and ATM were examined by fluorescence in situ hybridization and real-time quantitative polymerase chain reaction. Chromosomal imbalances were detected in 25 (58%) ALK-positive and 20 (65%) ALK-negative ALCL. ALK-positive ALCL with NPM-ALK or other ALK variant translocations showed a similar profile of secondary genetic alterations. Gains of 17p and 17q24-qter and losses of 4q13-q21, and 11q14 were associated with ALK-positive cases (P = 0.05), whereas gains of 1q and 6p21 were more frequent in ALK-negative tumours (P = 0.03). Gains of chromosome 7 and 6q and 13q losses were seen in both types of tumours. ALCL-negative tumours had a significantly worse prognosis than ALK-positive. However no specific chromosomal alterations were associated with survival. In conclusion, ALK-positive and negative ALCL have different secondary genomic aberrations, suggesting they correspond to different genetic entities.
Keywords:anaplastic large cell lymphoma    T-cell lymphoma    anaplastic lymphoma kinase    comparative genomic hybridization
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号