Galectin-3和VEGF表达水平与宫颈癌的相关性研究

目的：探讨宫颈癌组织表达半乳糖凝集素-3(Galectin-3)以及血管内皮生长因子(VEGF)水平与患者临床病理特征的相关性。方法选取2013年1月-2014年10月我院收治的139例宫颈癌患者作为研究对象，所有患者均采用免疫组化S-P法对宫颈癌组织行Galectin-3、VEGF表达水平检测，同时收集患者的年龄、肿瘤直径、淋巴结转移、病理学类型、宫颈间质浸润深度等临床病理特征指标。结果年龄＜45岁组与≥45岁组之间、鳞癌组与非鳞癌组之间、淋巴结转移阳性组与阴性组之间，宫颈癌组织表达Galectin-3、VEGF相比差异无统计学意义(P＞0.05)；宫颈间质浸润≤1/2肌层组与＞1/2肌层组之间、肿瘤直径≤2cm组与＞2cm组之间，宫颈癌组织表达Galectin-3、VEGF相比差异有统计学意义(P＜0.05)。结论宫颈癌组织表达Galectin-3以及VEGF与肿瘤直径、宫颈间质浸润深度等临床病理特征指标具有一定的相关性。

Galectin 3 and VEGF Expression Level and the Research of Cervical Cancer

Objective to investigate the cervical cancer tissue expressed galactosyl lectin-3 (Galectin-3) and vascular endothelial growth factor (VEGF) level and clinical pathologic features of patients with correlation. Methods Selection in October 2013 and January 2013-our hospital 139 cases of cervical cancer patients as the research object, all patients were using immunohistochemical S-P method for cervical cancer tissue Galectin 3, VEGF expression level detection, collected at the same time the patient's age, tumor size, lymph node metastasis, pathology type, clinical pathological characteristics of cervical stroma inifltration depth indicator. Results Age<45 years old group and acuity between 45 groups, between squamous carcinoma and squamous cell carcinomas group, lymph node metastasis between the positive and negative groups, compared to cervical cancer tissue expression Galectin 3, VEGF there was no statistically signiifcant difference (P>0.05). Cervical interstitial inifltrates 1/2 or less muscular layer and 1/2 muscular layer>group, tumor diameter 2 cm or less between, between group and>2 cm than cervical cancer tissue expression Galectin 3, VEGF difference was statistically signiifcant (P<0.05). Conclusion Cervical cancer tissue Galectin-3 and VEGF expression and tumor diameter, clinical pathological characteristics of cervical stroma inifltration depth indicator has a certain relevance.