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Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex
Authors:Herry Isabelle  Neukirch Catherine  Debray Marie-Pierre  Mignon Françoise  Crestani Bruno
Affiliation:1. Department of Nephrology, UZ Leuven, Leuven, Belgium;2. Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium;3. Department of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;4. Department of Research and Development, Gambro Dialysatoren GmbH, Hechingen, Germany;1. Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India;2. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India;3. Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India;4. Pediatric Biology Centre, Translational Health Science and Technology Institute, Government of India, Gurgaon, India;5. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India;1. Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan;2. Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan;3. Nakayamadera Imai Clinic, Takarazuka, Japan;4. Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan;5. Department of Nephrology in Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan;6. Division of Nephrology, Kanazawa Medical University School of Medicine, Uchinada, Japan;7. Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan;8. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan;9. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan;10. General Medical Research Center, Fukuoka University School of Medicine, Fukuoka, Japan
Abstract:Angiomyolipomas are very common in patients with tuberous sclerosis complex (TSC) and cause substantial morbidity. Until now, arterial embolization has been the recommended treatment for symptomatic patients. We report the case of a woman with TSC and giant angiolipomas in whom sirolimus induced a dramatic reduction in bilateral renal tumors.
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